Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 205-793-9 | CAS number: 151-56-4
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Original language, not translated.
Data source
Reference
- Reference Type:
- publication
- Title:
- Specific effects of ethyleneimine during its chronic action through inhalation
- Author:
- FOMENKO VN, ZAEVA GN, CHIRKOVA EM, KATOSOVA LD, STREKALOVA EE, ORDYNSKAYA NN
- Year:
- 1 976
- Bibliographic source:
- GIG TR PROF ZABOL; (6). 1976 24-29
Materials and methods
- GLP compliance:
- no
Test material
- Reference substance name:
- Aziridine
- EC Number:
- 205-793-9
- EC Name:
- Aziridine
- Cas Number:
- 151-56-4
- Molecular formula:
- C2H5N
- IUPAC Name:
- aziridine
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 4 months
Doses / concentrationsopen allclose all
- Remarks:
- Doses / Concentrations:
0.8/0.2 mg/m3
Basis:
- Remarks:
- Doses / Concentrations:
0.16/0.04 mg/m3
Basis:
Results and discussion
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Ethyleneimine produced gonadotropic, mutagenic and blastomogenic effects during a 4 months inhalation in rats.
- Executive summary:
Specific effects (namely gonadotropic, mutagenic and blastomogenic) of ethyleneimine (EI) were contrasted during chronic (4 months) action through inhalations on rats in 2 concentrations (0.8 | 0.2 and 0.16 | 0.04 mg/m3). Under the effect of a higher concentration a correlation of all 3 types of specific action was observed. With the action of the lower concentration, which did not produce a general toxic effect, there were still noted minimal manifestations of the gonadotropic and mutagenic action of EI, supporting the elective nature of the effect. More distinct changes in the indices of the gonadotropic and mutagenic action of EI in both concentrations, as compared with the blastomogenic one, point to their prognostic role.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
