Registration Dossier
Registration Dossier
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EC number: 202-851-5 | CAS number: 100-42-5
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Referred in a recognized source of peer reviewed scientific data on chemicals
Data source
Reference
- Reference Type:
- publication
- Title:
- Dermal Absorption of Organic Chemical Vapors in Rats and Humans.
- Author:
- McDougal et al.
- Year:
- 1 990
- Bibliographic source:
- Fundamental and Applied Toxicology, Vol. 14: 299 -308.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: skin absorption study
- Principles of method if other than guideline:
- Study investigated: the dermal penetration of styrene vapour via rats skin (in vivo study).
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Styrene
- EC Number:
- 202-851-5
- EC Name:
- Styrene
- Cas Number:
- 100-42-5
- Molecular formula:
- C8H8
- IUPAC Name:
- ethenylbenzene
- Test material form:
- other: vapour
Constituent 1
- Radiolabelling:
- yes
Results and discussion
Any other information on results incl. tables
Study observed:
Skin permeability constant: 1.75 cm/hr
Skin uptake of styrene in a mixed exposure (through the respiratory tract and through the skin): 9.4% of the total uptake.
Applicant's summary and conclusion
- Conclusions:
- Skin uptake of vapour styrene in rats was reported to be low.
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