Registration Dossier
Registration Dossier
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EC number: 241-629-2 | CAS number: 17647-86-8
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1978-09-12 to 1978-09-27
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable study report
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1979
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Potassium N,N-dimethylglycinate
- EC Number:
- 241-629-2
- EC Name:
- Potassium N,N-dimethylglycinate
- Cas Number:
- 17647-86-8
- Molecular formula:
- C4H8NO2.K
- IUPAC Name:
- potassium 2-(dimethylamino)acetate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: WIGA, Sulzfeld, Germany
- Weight at study initiation: males: 220 - 260 g; females: 180 - 190 g
- Fasting period before study: 15 to 20 hours before application
- Diet: standardized animal laboratory diet
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 21.5 and 50 % (G/V)
MAXIMUM DOSE VOLUME APPLIED: 10 mL/kg - Doses:
- 2150 and 5000 mg/kg
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Results and discussion
Effect levelsopen allclose all
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: One female in the 5000 mg/kg group was found dead after one day.
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 250 mg/kg bw
- Based on:
- act. ingr.
- Mortality:
- Male animals: no deaths after 14 days
Female animals: 2150 mg/kg: no deaths after 14 days; 5000 mg/kg: 1/5 after 14 days - Clinical signs:
- other: 5000 mg/kg: staggering, dyspnea, apathy, poor general state
- Gross pathology:
- Sacrificed animals: nothing abnormal detected
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
