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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Justification for type of information:
Data from peer reveiw publication

Data source

Reference
Reference Type:
publication
Title:
INHALATION TOXICOLOGY OF METHYLAMINE
Author:
A. Kinney, R. Valentine, H. C. Chen, R. M. Everett, and G. L. Kennedy,
Year:
1990
Bibliographic source:
Inhalation Toxicology, 2:29-39, 1990

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
To evaluate the acute toxicity of Methylamine hydrochloride in rats.
GLP compliance:
no
Test type:
acute toxic class method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Methylammonium chloride
EC Number:
209-795-0
EC Name:
Methylammonium chloride
Cas Number:
593-51-1
Molecular formula:
CH5N.ClH
IUPAC Name:
methanamine
Constituent 2
Reference substance name:
Methylamine hydrochloride
IUPAC Name:
Methylamine hydrochloride
Details on test material:
- Name of test material (as cited in study report): Methylamine hydrochloride
- Molecular formula (if other than submission substance): CH5N.Cl H

- Molecular weight (if other than submission substance): 67.5184 g/mol
- Substance type: Organic
- Physical state:
Purity No data available.
Specific details on test material used for the study:
- Name of test material (as cited in study report): Methylamine hydrochloride (methanaminium chloride)
- Molecular formula (if other than submission substance): CH5N.Cl H
- Molecular weight (if other than submission substance): 67.5184 g/mole
- Substance type: Organic

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
No data available.
Doses:
1600 to 3200 mg/kg
No. of animals per sex per dose:
No data available.
Control animals:
not specified
Details on study design:
No data available.
Statistics:
No data available.

Results and discussion

Preliminary study:
No data available.
Effect levels
Sex:
not specified
Dose descriptor:
LD50
Effect level:
1 600 mg/kg bw
Based on:
test mat.
95% CL:
1 600 - 3 200
Remarks on result:
other: 50 % mortality observed
Mortality:
50 % mortality was observed.
Clinical signs:
other: No data available.
Gross pathology:
No data available.
Other findings:
No data available.

Applicant's summary and conclusion

Interpretation of results:
Toxicity Category IV
Conclusions:
LD50 was considered to be 1600 mg/kg for Methylamine hydrochloride in rats by oral administration.
Executive summary:

In a acute oral toxicity study, rats were treated with methanaminium chloride orally. The LD50 was observed at the dose level of 1600 mg/kg bw in the range of 1600 to 3200 mg/kg.