Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 203-837-1 | CAS number: 111-13-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from peer reviewed journal
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- Monograph on fragrance raw materials, METHYL HEXYL KETONE
- Author:
- Edited by D. L. J. Opdyke
- Year:
- 1 975
- Bibliographic source:
- Food and Cosmetics Toxicology Volume 13, Issue 6 pp 861, 1975
- Reference Type:
- review article or handbook
- Title:
- Investigation of selected potential of contaminants: Ketonic Solvents
- Author:
- Sheldon S Lande, Patrick R Durkin, Deborah H Christopher, Philip H Howard, Jitendra Saxena
- Year:
- 2 003
- Bibliographic source:
- EPA-560/2-76-003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: as mentioned below
- Principles of method if other than guideline:
- An acute inhalation study was carried out on guinea pigs to estimate the inhalation toxicity of ketonic vapors
- GLP compliance:
- no
- Test type:
- other: No data
- Limit test:
- no
Test material
- Reference substance name:
- Octan-2-one
- EC Number:
- 203-837-1
- EC Name:
- Octan-2-one
- Cas Number:
- 111-13-7
- Molecular formula:
- C8H16O
- IUPAC Name:
- octan-2-one
- Details on test material:
- - Name of test material: 2-octanone
- IUPAC name: octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.2134 g/mol
- Substance type: Organic
- Physical state: Liquid
Constituent 1
- Specific details on test material used for the study:
- - Name of test material: 2-octanone
- IUPAC name: octan-2-one
- Molecular formula: C8H16O
- Molecular weight: 128.2134 g/mol
- Substance type: Organic
- Physical state: Liquid
Test animals
- Species:
- guinea pig
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No data
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- other: saturated atmosphere
- Vehicle:
- not specified
- Details on inhalation exposure:
- Guinea-pig was exposed to an essentially saturated atmosphere (1300 ppm)
- Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 14 h
- Concentrations:
- 1300 mg/L
- No. of animals per sex per dose:
- No data available
- Control animals:
- not specified
- Details on study design:
- Details on study design
Duration of observation period following administration: 14 days (or other?): clinical signs, behavioral changes were examined. - Statistics:
- No data available
Results and discussion
- Preliminary study:
- No data available
Effect levelsopen allclose all
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC50
- Effect level:
- > 1 300 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 14 h
- Remarks on result:
- other: no other details specified
- Key result
- Sex:
- not specified
- Dose descriptor:
- LC0
- Effect level:
- 1 300 mg/L air
- Based on:
- test mat.
- Exp. duration:
- 14 h
- Remarks on result:
- other: No mortality observed
- Mortality:
- No mortality was observed in treated guinea pig till 1300 mg/L, LC50 was considered as > 1300 mg/L
- Clinical signs:
- other: Nasal irritation developed immediately after the guinea-pig was exposed to an essentially saturated atmosphere (1300 mg/lt) This was followed by muscular weakness after exposure for approximately 10 hr and by coma after approximately 12 hr
- Body weight:
- No data available
- Gross pathology:
- No data available
- Other findings:
- No data available
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- As no mortality was observed in treated guinea pig till 1300 mg/L of exposed test chemical for 14 hrs, the acute inhalation LC50 was considered as > 1300 mg/L (i.e. 1300000 mg/m3).
- Executive summary:
In a acute inhalation toxicity study, guinea pig were exposed with test chemical in the concentration of 1300 mg/L in saturated atmosphere for 14 hours. No mortality was observed in treated guinea pig at 1300 mg/L and Nasal irritation developed immediately after the guinea-pig was exposed to an essentially saturated atmosphere (1300 mg/lt). This was followed by muscular weakness after exposure for approximately 10 hr and by coma after approximately 12 hr. As no mortality was observed in treated guinea pig till 1300 mg/L of exposed test chemical, acute inhalation LC50 was considered as > 1300 mg/L.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.