Registration Dossier
Registration Dossier
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EC number: 906-550-6 | CAS number: -
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- sub-chronic toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- disregarded due to major methodological deficiencies
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: secondary literature: experimental details are missing, only one dose used
Data source
Reference
- Title:
- Inhalational effect of cresol isomers at low concentrations and means for improving detoxication processes in experiments on white rats.
- Author:
- Pereima VL
- Year:
- 1 975
- Bibliographic source:
- Dissertation, Lvov, pp. 86-90, cited in: IPCS (1995), Environmental Health Criteria Report No. 168 : Cresols, Inte
Materials and methods
- Principles of method if other than guideline:
- Method: other
- GLP compliance:
- not specified
Test material
- Reference substance name:
- p-cresol
- EC Number:
- 203-398-6
- EC Name:
- p-cresol
- Cas Number:
- 106-44-5
- Molecular formula:
- C7H8O
- IUPAC Name:
- 4-methyl-phenol
- Reference substance name:
- p.cresol
- IUPAC Name:
- p.cresol
- Details on test material:
- IUCLID4 Test substance: other TS: p-cresol, no purity reported
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- female
Administration / exposure
- Route of administration:
- inhalation
- Duration of treatment / exposure:
- 4 months
- Frequency of treatment:
- daily
Doses / concentrations
- Dose / conc.:
- 0.01 mg/L air
- Control animals:
- other: no data specified
- Details on study design:
- Post-exposure period: 2 months
Results and discussion
Effect levels
- Dose descriptor:
- LOAEL
- Effect level:
- 0.01 mg/L air
- Sex:
- female
- Basis for effect level:
- body weight and weight gain
- clinical signs
- dermal irritation
- food consumption and compound intake
- organ weights and organ / body weight ratios
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
Clinical signs of toxicity included loss of appetite, marked
emaciation and decreased locomotor activity. Irritative
effects, which persisted throughout recovery, were seen on
the nose, eye and skin. Decreased body weight gain and lung
weight, increased liver weight, oliguria and dystrophic
changes in the lung and liver occurred.
Throughout recovery the body weights remained depressed and urinary excretion remained low.
Applicant's summary and conclusion
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