Registration Dossier
Registration Dossier
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EC number: 253-410-9 | CAS number: 37224-61-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- not reported
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Limited information on materials and methods is provided; it is therefore not possible to assess the reliability of the relevant results.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 969
- Report date:
- 1969
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The study was performed on 10 albino rabbits according to the method described under Section 191.10 of the Final Order, Enforcement Regulations, Federal Register, Vol. 26, No. 155, P. 7336, 12 August 1961.
- GLP compliance:
- no
- Remarks:
- study pre-dates GLP
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Isooctyldinitrophenol
- EC Number:
- 253-410-9
- EC Name:
- Isooctyldinitrophenol
- Cas Number:
- 37224-61-6
- Molecular formula:
- C14H20N2O5
- IUPAC Name:
- 4-(6-methylheptyl)-3,5-dinitrophenol
Constituent 1
Test animals
- Species:
- rabbit
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS - 10 albino rabbits
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Duration of exposure:
- not reported
- Doses:
- 200 mg/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 200 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
None of the animals died during the study (0/10).
Applicant's summary and conclusion
- Conclusions:
- The acute dermal LD50 of the test material was reported to be in excess of 200 mg/kg to rabbits.
- Executive summary:
The study was performed on 10 albino rabbits according to the method described under Section 191.10 of the Final Order, Enforcement Regulations, Federal Register, Vol. 26, No. 155, P. 7336, 12 August 1961.
During the study 10 rabbits received 200 mg/kg test material to a site of intact skin. None of the animals died during the study. The acute dermal LD50 was therefore reported to be in excess of 200 mg/kg.
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