Registration Dossier
Registration Dossier
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EC number: 931-313-9 | CAS number: -
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Adopted according to OECD SIDS (public available peer reviewed source). The original source is not available and has not been reviewed.
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- 1,4-Dichlorobut-2-ene- CAS No: 764-41-0
- Author:
- OECD SIDS
- Year:
- 2 006
- Bibliographic source:
- SIDS Initial Assessment Report for 22th SIAM, UNEP Publications
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 956
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Method: other: no data
- GLP compliance:
- no
- Remarks:
- was not mandatory at the time of the study
Test material
- Reference substance name:
- 1,4-dichlorobut-2-ene
- EC Number:
- 212-121-8
- EC Name:
- 1,4-dichlorobut-2-ene
- Cas Number:
- 764-41-0
- Molecular formula:
- C4H6Cl2
- IUPAC Name:
- 1,4-dichlorobut-2-ene
- Details on test material:
- Refined material A 9948 containing 20% cis-1,4-dichlorobut-2-ene, 45% trans-1,4-dichlorobut-2-ene and 35% 3,4-dichlorobut-1-ene.
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- 6 days
- Frequency of treatment:
- once daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
100 mg/kg bw/d
Basis:
- Control animals:
- not specified
Results and discussion
Results of examinations
- Details on results:
- CLINICAL SIGNS AND MORTALITY
5/6 animals died after 6 doses. Clinical signs: discomfort, diarrhoea after the third treatment, steady decline in body weight during the whole observation period.
GROSS PATHOLOGY
On pathological examination the animals which had died were found to have congested lungs and acute necrosis of the stomach, liver and spleen. The one rat which had survived the 6 treatments showed an ulceration of the stomach.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
