4-methoxybenzyl alcohol

Water solubility

Link to relevant study record(s)

Reference

Endpoint:

water solubility

Type of information:

experimental study

Adequacy of study:

key study

Study period:

2016-02-29 to 2016-03-04

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

OECD Guideline 105 (Water Solubility)

Version / remarks:

1995

Deviations:

no

Qualifier:

according to guideline

Guideline:

EU Method A.6 (Water Solubility)

Deviations:

no

GLP compliance:

yes (incl. QA statement)

Remarks:

Noack Laboratorien GmbH Käthe-Paulus-Str. 1 31157 Sarstedt Germany

Type of method:

flask method

Key result

Water solubility:

37.2 g/L

Conc. based on:

test mat.

Loading of aqueous phase:

100 g/L

Incubation duration:

72 h

Temp.:

20 °C

pH:

6.7

Details on results:

Preliminary Test (non GLP): The determined solubility in double distilled water was in the range of 4.915 - 19.66 g/L. For the application dose for the definitive study, 100 g/L, as ca. the fivefold of the maximum solubility result, was used.
Check of the pH-Value: The pH-values were determined with the remaining test item mixtures in the original test vessels, which were kept constant at 20 ± 0.5 °C.

pH-Value of the Test Item Mixtures and Double Distilled Water (Control)

 

Test temperature [°C]	Preincubation time [h]	Replicate	Measured pH	Mean value
20	24	1	6.826	6.7
		2	6.479
	48	1	6.623
		2	6.974
	72	1	6.682
		2	6.825
		Control	5.995	-

 

 

Water Solubility Results at 20 °C

 

Preincubation time [h]	Replicate	Test item [g/L]
		concentration	Mean
24	1	36.4	37.1
	2	37.9
48	1	36.8	37.2
	2	37.5
72	1	36.4	37.3
	2	38.3
Mean (24 – 72h)			37.2
Deviation			0.5

 

Conclusions:

The water solubility of the test item was determined to be 37.2 g/L at 20±0.2 °C.

Executive summary:

A study was conducted according to OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C. The analytical method (HPLC-DAD, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility of the test item was determined to be: 37.2 g/L (20 °C, pH 6.7).

Description of key information

The water solubility of the test item was determined to be 37.2 g/L at 20±0.2 °C.

Key value for chemical safety assessment

Water solubility:

37.2 g/L

at the temperature of:

20 °C

Additional information

A study was conducted according to OECD Guideline 105 for Testing of Chemicals (1995) and Council Regulation (EC) No. 260/2014, Method A.6. The solubility of the test item was determined using the flask method at 20 ± 0.5 °C with pre-incubation at 30 ± 0.5 °C. The analytical method (HPLC-DAD, external standard) for the determination of the test item was validated and tested with satisfactory results in regard to linearity, accuracy, precision and specificity. The water solubility of the test iem was determined to be: 37.2 g/L (20 °C, pH 6.7).