Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 211-637-0 | CAS number: 677-21-4
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Additional information
Justification for classification or non-classification
In a 4-week rat inhalation study performed according to OECD Guideline 412 at concentrations of 500, 1500, 5000, and 15000 ppm, no NOAEC was observed (LOAEC of 500 ppm) based on myocardial vacuolation and focal and multifocal mononuclear cell infiltrate ascribed to a direct toxic effect on the myocardial fibers and to the effects on blood vasculature, respectively (TNO, 2010).Additionally in a second 4-week rat inhalation study (Huntingdon Life Sciences, 2010). performed according to Guideline 412 at measured concentrations of 4967, 14953, and 49686 ppm, no NOEC was determined based on myocardial vacuolation/myofibre degeneration in all groups. Myocardial fibrosis and myocardial congestion (males) was observed at 14593 and 49686 ppm. Therefore, the test substance is classified as as Xn; R48/20 (Harmful: danger of serious damage to health by prolonged exposure through inhalation) according to EU Directive 67/548/EEC and STOT Rep Exp. 2 (H373: May cause damage to organs [blood vessels; heart] through prolonged or repeated inhalation exposure) according to EU Classification, Labelling and Packaging of Substances and Mixtures (CLP) Regulation (EC) No. 1272/2008.
References:
TNO (2010). A sub-acute (28-day) inhalation toxicity study with 3,3,3-trifluoroprop-1-ene (HFO-1243zf) in rats. Unpublished data, TNO Report No. V8668, A sub-acute (28-day) inhalation toxicity study with 3,3,3-trifluoroprop-1-ene (HFO 1243zf) in rats (December 3); TSCA Section 8e submission, 8EHQ-0111-17890C.
Huntingdon Life Sciences (2010). Unpublished data, HLS study number AST0031. 3,3,3-Trifluoroprop-1-ene (HFO 1234zf): Toxicity study by inhalation administration to CD rats for 4 weeks (November 2010); cited in TSCA 8e submission, 8EHQ-09-17629.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
