Registration Dossier
Registration Dossier
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EC number: 616-370-7 | CAS number: 76686-31-2
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: study performed according to OECD and GLP guidelines
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 997
- Report date:
- 1997
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- Phosphonium, [(2E,4E)-5-[(4R)-4-hydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl]-3-methyl-2,4-pentadienyl]triphenyl-, chloride
- EC Number:
- 616-370-7
- Cas Number:
- 76686-31-2
- Molecular formula:
- C33H38ClOP
- IUPAC Name:
- Phosphonium, [(2E,4E)-5-[(4R)-4-hydroxy-2,6,6-trimethyl-1-cyclohexen-1-yl]-3-methyl-2,4-pentadienyl]triphenyl-, chloride
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- New Zealand White
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- clipped
- Vehicle:
- water
- Controls:
- no
- Duration of treatment / exposure:
- 4 h
- Observation period:
- 72 h
- Number of animals:
- 3
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 0 - 72h
- Score:
- 0
- Max. score:
- 0
- Other effects:
- no observed effects
Any other information on results incl. tables
-
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Substance is not irritating
- Executive summary:
To assess the primary skin irritation potential of Zeyanl salt, a primary skin irritation
study was performed in three (one male and two females) young adult New Zealand White rabbits.
The fur of the left flank was clipped and 0.5 g of the substance was applied epicutaneously
to an area of approximately 6 cm2 and then covered with a semi-occlusive dressing for
approximately 4 hours. After removal of the dressing and test article, the skin reactions
(erythema and eschar, as well as oedema formation) were evaluated at 1, 24, 48 and 72 hours
after application. The primary irritation score was calculated to reflect and classify the irritant
potential of the test article. The dermal exposure to Zeanyl salt did not cause cutaneous irritation in any animal.
The Primary Irritation Score for the substance was 0.00 (the maximum attainable score is 8.0).
Following evaluation of the experimental data according to the EEC classification criteria,
it is classified as "not irritating" to rabbit skin.
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