Registration Dossier
Registration Dossier
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EC number: 620-216-4 | CAS number: 298692-41-8
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2006-09-27 - 2007-01-24
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP-study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 407 (Repeated Dose 28-Day Oral Toxicity Study in Rodents)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Limit test:
- no
Test material
- Reference substance name:
- isopropyl (diaminophosphoryl) carbamate
- Cas Number:
- 298692-41-8
- Molecular formula:
- C4H12N3O3P
- IUPAC Name:
- isopropyl (diaminophosphoryl) carbamate
- Reference substance name:
- Carbamic acid, (diaminophosphinyl)-1-methylethylester
- IUPAC Name:
- Carbamic acid, (diaminophosphinyl)-1-methylethylester
Constituent 1
Constituent 2
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Analytical verification of doses or concentrations:
- yes
- Duration of treatment / exposure:
- 28 day
- Frequency of treatment:
- once daily
Doses / concentrations
- Remarks:
- Doses / Concentrations:
1, 5, 50 and 500 mg/kg b.w.
Basis:
nominal in water
- No. of animals per sex per dose:
- 1, 5, 50 mg/kg b.w.: 5 animal per sex
500 mg/kg b.w.: 10 animal per sex - Control animals:
- yes
Results and discussion
Effect levels
open allclose all
- Dose descriptor:
- NOAEL
- Effect level:
- 50 mg/kg bw/day (nominal)
- Sex:
- male/female
- Dose descriptor:
- NOEL
- Effect level:
- 1 mg/kg bw/day (nominal)
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- NOAEL: 50 mg/kg b.w./day
NOEL: 1 mg/kg b.w./day - Executive summary:
NOAEL: 50 mg/kg b.w./day NOEL: 1 mg/kg b.w./day
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