Registration Dossier
Registration Dossier
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EC number: 204-857-3 | CAS number: 127-68-4
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- other: only orientating information about acute toxicity
- Rationale for reliability incl. deficiencies:
- other: only orientating information
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 961
- Report date:
- 1961
Materials and methods
- Principles of method if other than guideline:
- according to BASF-internal standard
- GLP compliance:
- no
Test material
- Reference substance name:
- Sodium 3-nitrobenzenesulphonate
- EC Number:
- 204-857-3
- EC Name:
- Sodium 3-nitrobenzenesulphonate
- Cas Number:
- 127-68-4
- Molecular formula:
- C6H5NO5S.Na
- IUPAC Name:
- sodium 3-nitrobenzenesulphonate
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- Name of the test substance used in the study report: Ludigol
Purity: 95%
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- other: Tuebinger
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- water
- Doses:
- 4-30% solution (= 400, 800, 1600 or 3200 mg/kg)
- No. of animals per sex per dose:
- 10
- Control animals:
- not specified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 300 mg/kg bw
- Mortality:
- 400, 800 and 1600 mg/kg: no animal died
3200 mg/kg: 9/10 males and 10/10 females after 24 hours - Clinical signs:
- As a reaction to the high dose (3200 mg/kg b.w.), the animals showed strong tonic convulsion and dyspnea. Some mice died within 24 h.
- Gross pathology:
- Gross pathological examination of the deceased animals revealed redness of the small intestine at the site of injection. The animals that were sacrificed at the end of the observation period were without pathological findings.
Applicant's summary and conclusion
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Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
