Registration Dossier
Registration Dossier
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EC number: 215-168-2 | CAS number: 1309-37-1
Exposure related observations in humans: other data
Administrative data
- Endpoint:
- exposure-related observations in humans: other data
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: detailed report available
Data source
Reference
- Title:
- No information
- Author:
- Lay JC, Zeman KL, Ghio AJ, Bennett WD (2001). Effect of inhaled iron oxide particles on alveolar epithelial permeability in normal subjects. Inhalation Toxicol 13, 1065-1078.
Materials and methods
- Type of study / information:
- Type of experience: other: alveolar epithelial permeability after inhalation of Fe2O3
- Principles of method if other than guideline:
- Sixteen healthy subjects inhaled aerosols or iron oxide particles. Alveolar epithelial permeability was assessed by measuring the pulmonary clearance of an inhaled radiolabeled tracer molecule using a gamma camera at 0.5 and 24 h post particle exposure. Carbon monoxide lung diffusing capacity and spirometry were also performed before and after breathing the iron oxide
Test material
- Reference substance name:
- Diiron trioxide
- EC Number:
- 215-168-2
- EC Name:
- Diiron trioxide
- Cas Number:
- 1309-37-1
- Molecular formula:
- Fe2O3
- IUPAC Name:
- diiron(3+) trioxidandiide
- Details on test material:
- Fe2O3; particle size = 1.5 µm
Constituent 1
Results and discussion
- Results:
- Neither iron oxide with high nor low content of soluble iron had any effect on the permeability of the respiratory epithelium in humans
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
