Registration Dossier
Registration Dossier
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EC number: 231-633-2 | CAS number: 7664-38-2
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Code of Federal Regulations, section 1500.42
- GLP compliance:
- no
Test material
- Reference substance name:
- MCTR-1-75
- IUPAC Name:
- MCTR-1-75
- Details on test material:
- MCTR 1-75 identified by written note as 85% phosphoric acid
Constituent 1
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 2.0 - 2.5 kg
- Housing: individual cages
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
Test system
- Vehicle:
- unchanged (no vehicle)
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 mL - Duration of treatment / exposure:
- 7 days - eyes were not washed after test substance administration
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
SCORING SYSTEM: Federal Regsiter. Vol 38, No. 187 - September 27, 1973 p27019
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 96
- Max. score:
- 100
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 48 h
- Score:
- 98
- Max. score:
- 100
- Reversibility:
- not fully reversible within: 7 days
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- 72 h
- Score:
- 100
- Max. score:
- 100
- Reversibility:
- not fully reversible within: 7 days
- Other effects:
- The test substance produced severe irritation for the duration of 7 days when instilled into the eye and not washed out. The product, when tested in accordance with the Federal Hazardous Substance Labeling Act, is considered to be a severe eye irritant.
Applicant's summary and conclusion
- Interpretation of results:
- other: 85% phosphoric acid was considered to be a 'severe irritant'
- Conclusions:
- Identified by hand as 85% phosphoric acid but as information of substance identity and purity was not confirmed not possible to conclude that the results are assignable to phosphoric acid. Nevertheless the irritation effects observed on eyes are similar to effects observed on other tests for 85% phosphoric acid.
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