Registration Dossier
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Diss Factsheets
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EC number: 206-557-8 | CAS number: 354-33-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
Additional information
HFC-125 was assessed for the potential to be metabolised to trifluoroacetic acid in liver, in comparison with other halogenated-ethanes. Male Fisher rats were exposed to halothane, HCFC-124, HFC-125, HCFC-123 and HFC-134a. At the end of the exposure, animals were placed in metabolism cages and urinary trifluoroacetic acid excretion was measured. The presence of trifluoroacetylated-hepatic protein was assessed by means of SDS-PAGE and immunoblotted with anti-TFA-protein serum. The potential to form trifluoroacetylated-hepatic protein has the following decreasing order: Halothane >= HCFC-123 >> HCFC-124 > HFC-125. TFA-proteins were not detected in samples from rats exposed to HFC-134a. 19F-NMR analysis of urinary TFA excretion confirmed the previous order of reactivity. The increased fluorination on the dihalomethyl group (-CX2H) decreases the metabolism of these compounds in vivo. HFC-125 showed a lower potential to form TFA in liver when compared to other halogenated ethanes.
Sprague Dawley rats were exposed to 1,000, 5,000 and 50,000 ppm (4,900, 24,500 and 245,000 mg/m3) HFC-125 for 6 hours in individual inhalation chambers (Anders, 1993). Absorption was calculated by measuring the decrease of HFC-125 concentration in atmosphere within the period of exposure. Results indicated a slight uptake at the end of the exposure period. Due to the low absorption of HFC-125, kinetic constants of uptake and metabolism were not calculated.
Conclusion
HFC-125 is very poorly absorbed via inhalation. Compared with other hydrofluorocarbons or hydrochlorofluorocarbons, HFC-125 is less likely to be metabolised to TFA in the liver or will be metabolized at a slower rate.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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