Registration Dossier
Registration Dossier
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EC number: 200-751-6 | CAS number: 71-36-3
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1967
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 967
- Report date:
- 1967
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- Principles of method if other than guideline:
- Test material was administered by oral gavage to rats at various dose levels. Survivors were observed for 14 days after dosing.
- GLP compliance:
- no
- Test type:
- standard acute method
- Limit test:
- no
Test material
- Reference substance name:
- Butan-1-ol
- EC Number:
- 200-751-6
- EC Name:
- Butan-1-ol
- Cas Number:
- 71-36-3
- Molecular formula:
- C4H10O
- IUPAC Name:
- butan-1-ol
- Test material form:
- liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Harlan Wistar
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- unchanged (no vehicle)
- Doses:
- Dosage levels differ by a factor of 2 in a geometric series.
- No. of animals per sex per dose:
- Number of female rats used not stated in report but typically 6 rats are used/dose level.
- Control animals:
- not specified
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- ca. 2 292 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: converted value (calculated with a density 0.81 g/mL)
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 2.83 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: original value
Any other information on results incl. tables
No additional information available.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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