Registration Dossier
Registration Dossier
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EC number: 204-826-4 | CAS number: 127-19-5
Hydrolysis
Administrative data
Link to relevant study record(s)
Description of key information
Under environmentally relevant conditions, the substance is assessed to be resistant to hydrolysis because it does not contain any labile functional groups. Moreover, the substance is readily biodegradable.
Key value for chemical safety assessment
Additional information
According to Regulation (EC) 1907/2006, Annex VIII, Section 9.2.2.1, Column 2, the study does not need to be conducted if the substance is readily biodegradable. The substance is readily biodegradable (Dir. 92/69/EEC, Part 7 (MITI I), equivalent to OECD 301 C; Biffi, 1995 cited in OECD SIDS (2001); 70% in 28 d (BOD/ThOD); see IUCLID Ch. 5.2.1). Therefore, no study on hydrolysis is performed.
A study, cited in the OECD SIDS 2004 and originally performed by DuPont (1988) indicates, that hydrolysis of N,N-dimethylacetamide (DMAC) is expected to occur only in very small amounts (< 0.5%) in acidic and alkaline solutions at elevated temperatures (> 30 °C) and long exposure (11 days). These findings are supported by the results of a test performed by Nellis (1965) and by a statement within the Hazardous Substance Database (Toxnet), that DMAC will probably hydrolyse slowly within the aquatic environment.
According to Kollig et al. (1993), Boethling & Mackay (2000) and Harris (1990), the substance is generally resistant to hydrolysis because it does not contain any labile functional groups. Therefore, no study on hydrolysis is performed.
Due to these results the aquatic tests are supposed to be valid as the test substance is assumed to be stable within the test solutions during the test performance.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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