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EC number: 204-469-4 | CAS number: 121-44-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: similar to guideline study; no data regarding GLP
Data source
Reference
- Reference Type:
- publication
- Title:
- Salmonella mutagenicity tests: III. Results from the testing of 255 chemicals
- Author:
- Zeiger, E. et al.
- Year:
- 1 987
- Bibliographic source:
- Environ. Mutagen. 9, Suppl. 9, 1-110,|(1987)
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- other: Haworth, S. et al.: Environ. Mutagen. 5, Suppl. 1, 3-142
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 471 (Bacterial Reverse Mutation Assay)
- Deviations:
- yes
- Remarks:
- no E. coli strain included
- Principles of method if other than guideline:
- Use of S. typhymurium strain TA98, TA100, TA1535, TA1537 and/or TA97, but no E.coli strain.
not toxic chemicals tested up to a maximum dose of 10 mg/plate, poorly soluble chemicals were tested up to the dose defined by solubility, A maximum of 0.05 ml solvent was added to each plate, only 2-Aminoanthracene was used as the indicator of the efficacy of the S9-Mix, not every individual plate count is displayed, no justification that no confirmation of the negative result has been made - GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Triethylamine
- EC Number:
- 204-469-4
- EC Name:
- Triethylamine
- Cas Number:
- 121-44-8
- Molecular formula:
- C6H15N
- IUPAC Name:
- triethylamine
- Details on test material:
- Triethylamine, no further data
Constituent 1
Method
- Target gene:
- his-
Species / strain
- Species / strain / cell type:
- other: Salmonella Typhimurium TA98, TA100, TA1535, TA1537, TA97
- Details on mammalian cell type (if applicable):
- not applicable
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- rat and hamster S9 (10% Aroclor 1254-induced)
- Test concentrations with justification for top dose:
- 0, 100, 333, 1000, 3333 and 10000 ug/plate
- Vehicle / solvent:
- 95% ethanol
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- yes
- Remarks:
- was run with each trial
- True negative controls:
- not specified
- Positive controls:
- yes
- Remarks:
- without S9: Sodium azide (TA1535, TA100), 9-aminoacridine (TA1537), 4-nitro-o-phenylenediamine (TA98) with S9: 2-aminoanthracene
- Positive control substance:
- not specified
- Details on test system and experimental conditions:
- SYSTEM OF TESTING
- Species/cell type: Salmonella typhimurium TA 100, TA 1535, TA1537, TA 98
- Deficiency: histidine
- Solvent: 95% ethanol
- Metabolic activation system: rat and hamster S9 (10% Aroclor 1254-induced)
ADMINISTRATION:
- Dosing: 0, 100, 333, 1000, 3333 and 10000 ug/plate
- Number of replicates: 3
- Application: plate incubation
- Positive and negative control groups and treatment: without S9: Sodium azide (TA1535, TA100), 9-aminoacridine (TA1537), 4-nitro-o-phenylenediamine (TA98) with S9: 2-aminoanthracene
- Pre-incubation time: 20 minutes
DESCRIPTION OF FOLLOW UP REPEAT STUDY: If initial test was equivocal or negative, repeat with other level of S9. - Evaluation criteria:
- An individual trial was judged mutagenic (+) if a dose-related increase over the corresponding solvent control was seen, and it was judged weakly mutagenic C+W) if a low-level dose response was seen. A trial was considered questionable (?) if a dose related
increase was judged insufficiently high to justify a call of " + W," if only a single dose was elevated over the control, or if a non-dose-related increase was seen.
The distinctions between a weak mutagenic response and a mutagenic response, or between a weak mutagenic response and a questionable mutagenic response are highly subjective.
A chemical was judged to be mutagenic (+), or weakly mutagenic (+W), if it produced a reproducible, dose-related increase in his+ revertants over the corresponding solvent controls in replicate trials. A chemical was considered to be questionable (?) if a reproducible increase of hist revertants did not meet the criteria for either a " + " or " + W," or if only single doses produced an increase in his+ revertants in repeat trials - Statistics:
- no data
Results and discussion
Test results
- Species / strain:
- S. typhimurium, other: all strains tested
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- cytotoxicity
- Remarks:
- >10000 ug/plate
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- valid
- Positive controls validity:
- valid
- Remarks on result:
- other: other:
- Remarks:
- Migrated from field 'Test system'.
Any other information on results incl. tables
Table 236. TRIETHYLAMINE (LAB: SRI VOLVENT: ET95) |
||||||||||||||||||
DOSE |
TA100 |
TA1535 |
||||||||||||||||
NA |
NA |
10% HLI |
10% HLI |
10% RLI |
10% RLI |
NA |
10% HLI |
10% RLI |
||||||||||
µg/plate |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
0.000 |
125 |
1.0 |
104 |
4.6 |
160 |
12.8 |
117 |
5.3 |
142 |
5.8 |
127 |
9.9 |
32 |
1.8 |
35 |
4.3 |
24 |
1.3 |
100.000 |
114 |
7.3 |
117 |
9.7 |
125 |
9.5 |
123 |
3.2 |
127 |
6.5 |
112 |
8.6 |
30 |
4.1 |
26 |
2.6 |
22 |
1.3 |
333.000 |
133 |
9.6 |
115 |
15.3 |
147 |
0.6 |
158 |
4.7 |
127 |
11.8 |
113 |
2.7 |
24 |
2.2 |
30 |
3.5 |
24 |
1.5 |
1.000.000 |
110 |
4.1 |
113 |
14.8 |
138 |
7.0 |
128 |
11.3 |
125 |
17.3 |
111 |
8.2 |
32 |
4.8 |
33 |
10.5 |
18 |
2.0 |
3.333.000 |
112 |
5.2 |
92 |
7.2 |
140 |
6.9 |
138 |
14.7 |
119 |
14.5 |
89 |
3.2 |
21 |
3.8 |
42 |
5.2 |
17 |
2.1 |
10000.000 |
t |
|
t |
|
129 |
0.9 |
t |
|
120 |
31.5 |
t |
|
t |
|
t |
|
4 |
2.1 |
POS |
277 |
18.4 |
419 |
12.6 |
1100 |
18.7 |
778 |
10.2 |
688 |
39.0 |
335 |
6.4 |
379 |
22.3 |
356 |
53.3 |
120 |
13.2 |
Table 236. TRIETHYLAMINE (CONTINUED) |
||||||||||||
DOSE |
TA1537 |
TA98 |
||||||||||
NA |
10% HLI |
10% RLI |
NA |
10% HLI |
10% RLI |
|||||||
µg/plate |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
MEAN |
SEM |
0.000 |
6 |
0.6 |
7 |
0.7 |
15 |
1.2 |
18 |
3.8 |
26 |
2.9 |
33 |
4.0 |
100.000 |
8 |
1.0 |
6 |
0.6 |
9 |
0.3 |
29 |
4.5 |
35 |
5.1 |
26 |
5.4 |
333.000 |
8 |
1.9 |
6 |
0.7 |
6 |
0.3 |
18 |
2.0 |
32 |
5.8 |
26 |
2.7 |
1000.000 |
5 |
0.6 |
9 |
3.2 |
9 |
1.5 |
19 |
1.5 |
24 |
2.4 |
29 |
1.2 |
3333.000 |
6 |
0.6 |
8 |
0.7 |
5 |
1.9 |
12 |
1.3 |
34 |
3.9 |
15 |
4.5 |
10000.000 |
t |
|
3 |
2.0 |
2 |
0.5 |
t |
|
t |
|
|
|
POS |
211 |
25.1 |
454 |
17.6 |
204 |
14.8 |
730 |
18.6 |
457 |
34.3 |
401 |
33.1 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Triethylamine do not revert mutations in the Salmonella typhimurium. - Executive summary:
Salmonella typhimurium TA 100, TA 1535, TA1537, TA 98 were exposed to 0, 100, 333, 1000, 3333 and 10000 µg/plate using the pre-incubation method in either the presence or absence of 10% rat or hamster liver metabolic activation. The highest nontoxic dose tested was 3333 mg/plate (32.94 mmol/plate).
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