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EC number: 200-875-0 | CAS number: 75-50-3
Endpoint summary
Administrative data
Description of key information
Appearance / physical state / colour:
The appearance of Trimethylamine is observed to be a colorless volatile liquid organic compound.
Melting point/ Freezing point:
The freezing point of Trimethylamine is determined to be -117.1 °C.
Boiling point:
The boiling point of Trimethylamine is determined to be 2.87 °C.
Density:
The density of Trimethylamine is determined to be 0.627 g/cm3 at 25 °C.
Particle size distribution (Granulometry):
In accordance with column 2 of Annex VII of the REAcH regulation this end point was considered for waiver since the chemical Trimethylamine is a liquid and is expected to be marketed or used in a non solid or granular form.
Vapour pressure:
The vapour pressure of Trimethylamine is determined to be 193850.73 Pa at 21°C (1454 mmHg).
Partition coefficient:
The partition coefficient (n-octanol/water) of test substance Trimethylamine (CAS no. 75-50-3) was determined as per the HPLC method (OECD Guideline-117). The Log Pow value was determined to be 1.890 ± 0.009 dimensionless at 25°C. This value indicates that the substance Trimethylamine (CAS no. 75-50-3) is hydrophilic in nature.
Water solubility:
The water solubility for the test item Trimethylamine was found to be 422505 mg/L or 422.505 g/L at 25°C.
Surface tension:
The surface tension of is Trimethylamine determined to be 17.4 dynes/cm at -4°C.
Flash point:
The flash point of Trimethylamine is determined to be -6.66 °C (-7°C).
Autoflammability:
The auto-ignitation temperature (auto-flammability) of Trimethylamine is determined to be 190°C.
Flammability:
The study does not need to be conducted because the Trimethylamine is an extremely flammable liquid according GHS criteria and having flash point is -6.66°C (-7°C).
Explosiveness:
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties.
Oxidising properties:
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with oxidizing properties and hence the classification procedure does not need to be applied.
Dissociation constant:
The dissociation constant (pKa) of Trimethylamine is determined to be 9.80.
Viscosity:
The viscosity of Trimethylamine is determined to be 0.51564 mPa.sec (0.00051564 Pa.sec) at -73.15°C.
Additional information
Appearance / physical state / colour:
Based on available data from obtained report the appearance of Trimethylamine is observed to be a colorless volatile liquid organic compound.
Other supporting data from handbooks articles and authoritative databases also observed the appearance of Trimethylamine as liquefied compressed gas with pungent, fishy, ammoniacal odor.
Melting point/ Freezing point:
Based on available data from handbooks, authoritative databases and articles, the freezing point of Trimethylamine is determined to be -117.1 °C.
Boiling point:
Based on available data from handbooks, authoritative databases and articles, the boiling point of Trimethylamine is determined to be 2.87 °C.
Other supporting data from handbooks, authoritative databases and review articles, also determined the boiling point of Trimethylamine as 2.8 °C, 2.9 °C and 3.0 °C, very much closer to the selected key study value.
Density:
Based on available data from handbooks, review articles and authoritative databases, the density of Trimethylamine is determined to be 0.627 g/cm3 at 25 °C.
Other supporting data from handbooks, authoritative databases and review articles, also determined the density of Trimethylamine as
0.6709 g/cm3, 0.662 g/cm3 at -5 °C and 0.6534 g/cm3.
Particle size distribution (Granulometry):
In accordance with column 2 of Annex VII of the REAcH regulation this end point was considered for waiver since the chemical Trimethylamine is a liquid and is expected to be marketed or used in a non solid or granular form.
Vapour pressure:
Based on available data from handbook, review article and authoritative database, the vapour pressure of Trimethylamine is determined to be 193850.73 Pa at 21°C (1454 mmHg).
Other supporting data from review articles and authoritative databases, also determined the vapour pressure of Trimethylamine as 214649.02 Pa at 21°C (1610 mmHg).
One more study from authoritative database Gestis, also exhibited the vapour pressure of Trimethylamine as 251.57931 Pa at 20°C, 333.306 Pa at 30°C and 599.951 Pa at 50°C.
Partition coefficient:
The partition Coefficient n-octanol/water of test chmeicalTrimethylamine (CAS no. 75-50-3)was determined by the Reverse Phase High Performance Liquid Chromatographic method according to OECD Guideline No. 117 for testing of Chemicals. The reference substances were chosen according to estimated Pow range of the test substance and generalized calibration graph was prepared.
The reference substances wereButanone, 4-Acetylpyridine, Acetanilide, Benzyl alcohol, 4-Methoxyphenol, Phenoxyacetic acid, Phenol, 4-Methylbenzyl alcohol, Acetophenone, 2-Nitrophenol, Nitrobenzene, Cinnamyl alcohol, Benzene, Methyl benzoate, Cinnamic Acid, Toluene, 2,6-Dichlorobenzonitrile, Chlorobenzene, 2,3-Dichloroaniline, Allyl phenyl ether, Bromobenzene,Benzophenone, Ethylbenzene, 1,4-Dichlorobenzene, Diphenylamine, Naphthalene, Biphenyl, Benzyl Benzoate, 1,2,4-Trichlorobenzene, Dodecanoic acid, Diphenyl ether, n-Butylbenzene, DDT, having Pow value ranging from 0.3 to 6.5.
The Log Pow value was determined to be1.890 ± 0.009dimensionless at 25°C.
This value indicates that the substanceTrimethylamine (CAS no. 75-50-3)is hydrophilic in nature.
Water solubility:
The water solubility determination of test item Trimethylamine (CAS No. 75-50-3) was done as per the OECD guideline 105 by spectrophotometric analytical method as per OECD 101. The solubility of (Trimethylamine of CAS No: 75-50-3) in water was found to be 422505 mg/L or 422.505 g/L at 25°C.
Other supporting data from handbooks and authoritative database, also determined the water solubility of Trimethylamine as 890000 mg/L at 30°C, 410000 mg/L at 19°C and 475000 mg/L at 25°C respectively.
Hence on the basis of obtained values the Trimethylamine is considered to be very soluble in water.
Surface tension:
Based on available data from handbook and authoritative databases, the surface tension of is Trimethylamine determined to be 17.4 dynes/cm at -4°C.
Flash point:
Based on available data from handbooks, authoritative databases and review articles, the flash point of Trimethylamine is determined to be -6.66 °C (-7°C).. Hence, according to the GHS criteria, the given chemical Trimethylamine is considered to be extremely flammable liquids and fallen under catagory 1.
Autoflammability:
Based on available data from handbooks and authoritative databases, the auto-ignitation temperature (auto-flammability) of Trimethylamine is determined to be 190°C.
Flammability:
The study does not need to be conducted because the Trimethylamine is an extremely flammable liquid according GHS criteria and having flash point is -6.66°C (-7°C).
Explosiveness:
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with explosive properties.
Oxidising properties:
The study does not need to be conducted because there are no chemical groups present in the molecule which are associated with oxidizing properties and hence the classification procedure does not need to be applied.
Dissociation constant:
Based on available data from authoritative databases, the dissociation constant (pKa) of Trimethylamine is determined to be 9.80.
Viscosity:
Based on available data from authoritative databases, the viscosity of Trimethylamine is determined to be 0.51564 mPa.sec (0.00051564 Pa.sec) at -73.15°C.
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