Registration Dossier
Registration Dossier
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EC number: 200-272-2 | CAS number: 56-40-6
Dermal absorption
Administrative data
- Endpoint:
- dermal absorption
- Type of information:
- (Q)SAR
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Justification for type of information:
- QSAR prediction
Data source
Reference
- Reference Type:
- other: QSAR Database
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Guideline:
- other: REACH guidance on QSARs R.6, May/July 2008
- Principles of method if other than guideline:
- Dermwin v2.01 (Q)SAR database report
Test material
- Reference substance name:
- Glycine
- EC Number:
- 200-272-2
- EC Name:
- Glycine
- Cas Number:
- 56-40-6
- Molecular formula:
- C2H5NO2
- IUPAC Name:
- glycine
Constituent 1
Results and discussion
- Absorption in different matrices:
- Dermal absorption of the test substance was predicted to be low with an estimated dermal permeability coefficient (Kp) of 4.37E-006 cm/h and a dermal absoprtion rate of 3.05E-003 mg/cm²/event. The maximum flux Imax (Imax = Kp [cm/h] x water solubility [mg/cm³]) was calculated, resulting in dermal absorption of 1 µg glycine/cm²/h.
Applicant's summary and conclusion
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