Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 906-627-4 | CAS number: -
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 403 (Acute Inhalation Toxicity)
- Version / remarks:
- (Inhalation hazard test)
- Deviations:
- yes
- Remarks:
- (only 6 hours of exposure, only 6 animals of one sex)
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Reaction mass of cyclohexanol and cyclohexanone
- EC Number:
- 906-627-4
- Molecular formula:
- Unspecified
- IUPAC Name:
- Reaction mass of cyclohexanol and cyclohexanone
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 260 g
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22
- Humidity (%): 70
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- not specified
- Vehicle:
- other: unchanged (no vehicle)
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure chamber volume: 35 l - Duration of exposure:
- 6 h
- Concentrations:
- 6.6 mg/l
- No. of animals per sex per dose:
- 6 males
- Control animals:
- no
Results and discussion
Effect levels
- Sex:
- male
- Dose descriptor:
- LC50
- Effect level:
- > 6.6 mg/L air
- Exp. duration:
- 6 h
- Remarks on result:
- other: no mortality occurred
- Mortality:
- No animals died
- Clinical signs:
- other: No toxic signs
- Body weight:
- Day 7: 330 g
Day 14: 390 g - Gross pathology:
- Viscera appeared normal
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
