Registration Dossier
Registration Dossier
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EC number: 203-941-7 | CAS number: 112-16-3
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Parent compound: no data available (not required according to information requirements)
Hydrolysis product lauric acid: With high probability chronically not toxic to aquatic invertebrates after pH-adjustment.
Key value for chemical safety assessment
Additional information
A study is not required according to the information requirements for this tonnage band.
No data are available for lauroyl chloride (CAS 112 -16 -3). The substance rapidly decomposes in water and forms HCl (CAS 7647 -01 -0) and lauric acid (CAS 143 -07 -7). Therefore, the long-term toxicity to aquatic invertebrates is assessed on the basis of data on lauric acid (CAS 143 -07 -7) and its sodium salt (sodium laurate, CAS 629 -25 -4).
Regarding chronic toxicity to aquatic invertebrates a test performed by the Japanese National Institute of Technology and Evaluation (1999) was identified as the key study. The test is performed according to OECD guideline 211 under GLP conditions. Further study details are only available in Japanese. The NOEC for Daphnia magna after 21 days of exposure is 0.47 mg/L. The 21 -d EC50 is 0.44 mg/L. The EC50 was determined to be lower than the NOEC which might be due to the test design and the significance of the observed endpoint (reproduction).
In the ECHA Registration Dossier for lauric acid, the key study has the same effect values: 21 -d NOEC = 0.47 mg/L, 21 -d EC50 = 0.44 mg/L (measured, dispersant used; ECHA, 2012).
In a read across approach to the structurally similar substance sodium laurate (CAS 629 -25 -4), a 21 -d NOEC of 100 mg/L was determined in an OECD 211 guideline study using Daphnia magna as test species. The test concentrations were analytically verified. Since sodium laurate does not cause a pH shift in water, this study can be regarded to be the result of the neutralised acid.
In conclusion the substance and its hydrolysis product lauric acid can be assessed to be with high probability not chronically toxic to aquatic invertebrates after pH-adjustment.
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