Ammonium hydrogendifluoride

Exposure related observations in humans: other data

Administrative data

Endpoint:

exposure-related observations in humans: other data

Type of information:

other: review

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Published peer reviewed paper

Data source

Reference

Reference Type:

publication

Title:

Risk assessment: ammonium bifluoride in industrial cleaning applications.

Author:

Daggett, D.A., Leikin, J.B., Bradshaw, B.D., Carrao, A.M., Heitfeld, F.A., Long, K.E., Ren, S., Hamilton, J.D.

Year:

2006

Bibliographic source:

Toxicological Sciences, 90(1-S): 332-333

Materials and methods

Type of study / information:

Risk assessment on the use of ammonium bifluoride in industrial cleaning applications

Test guideline

Qualifier:

no guideline followed

Principles of method if other than guideline:

Risk assessment on the use of ammonium bifluoride in industrial cleaning applications

GLP compliance:

not specified

Remarks:

: not relevant

Test material

Test material information

Constituent 1

Reference substance name:

Ammonium hydrogendifluoride

EC Number:

215-676-4

EC Name:

Ammonium hydrogendifluoride

Cas Number:

1341-49-7

Molecular formula:

F2H5N

IUPAC Name:

ammonium fluoride hydrofluoride

Details on test material:

Ammonium bifluoride is a water soluble white crystal with the chemical formula F2H5N.

Method

Ethical approval:

not applicable

Details on study design:

A risk assessment was performed to characterise the risks associated with intended use of ammonium bifluoride as an industrial cleaning agent.

Exposure assessment:

estimated

Details on exposure:

Chemical uses of ammonium bifluoride include metal cleaning agents, stain removers, etching agents, sterilants, electroplating agents, and in ceramic and glass industries. There have been cases of accidental ingestion of products containing ammonium bifluoride leading to a range of toxic effects including death. The assessment examines chronic fluoride exposure resulting from occupational use of an industrial cleaning product containing ammonium bifluoride. The chronic fluoride exposure model considered incidental ingestion, inhalation, and dermal exposure, with the aggregate absorbed dose being calculated.

Results and discussion

Results:

The results of the assessment reportedly indicate that intended use of ammonium bifluoride in industrial cleaning applications is not associated with unreasonable risk for adverse health outcomes.

Any other information on results incl. tables

The results of the assessment reportedly indicate that intended use of ammonium bifluoride in industrial cleaning applications is not associated with unreasonable risk for adverse health outcomes. The results of the risk assessment are not available for review.

Applicant's summary and conclusion

Conclusions:

The results of the assessment reportedly indicate that intended use of ammonium bifluoride in industrial cleaning applications is not associated with unreasonable risk for adverse health outcomes.

Executive summary:

Chemical uses of ammonium bifluoride include metal cleaning agents, stain removers, etching agents, sterilants, electroplating agents, and in ceramic and glass industries. There have been cases of accidental ingestion of products containing ammonium bifluoride leading to a range of toxic effects including death. The assessment examines chronic fluoride exposure resulting from occupational use of an industrial cleaning product containing ammonium bifluoride. The chronic fluoride exposure model considered incidental ingestion, inhalation, and dermal exposure, with the aggregate absorbed dose being calculated. The results of the assessment reportedly indicate that intended use of ammonium bifluoride in industrial cleaning applications is not associated with unreasonable risk for adverse health outcomes. The results of the risk assessment are not available for review