Registration Dossier
Registration Dossier
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EC number: 403-810-6 | CAS number: 140876-13-7 C.I. REACTIVE YELLOW 138:1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Body responsible for the test
- Title:
- Unnamed
- Year:
- 1 989
- Report date:
- 1989
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Annex V (limit test)
- GLP compliance:
- yes
- Limit test:
- yes
Test material
- Reference substance name:
- Potassium sodium 3,3'-(3(or4)-methyl-1,2-phenylenebis(imino(6-chloro)-1,3,5-triazine-4,2-diylimino(2-acetamido-5-methoxy)-4,1-phenylenazo)dinaphthalene-1,5-disulfonate
- EC Number:
- 403-810-6
- EC Name:
- Potassium sodium 3,3'-(3(or4)-methyl-1,2-phenylenebis(imino(6-chloro)-1,3,5-triazine-4,2-diylimino(2-acetamido-5-methoxy)-4,1-phenylenazo)dinaphthalene-1,5-disulfonate
- Cas Number:
- 140876-13-7
- Molecular formula:
- C51H42Cl2N16O16S4
- IUPAC Name:
- 3-{2-[4-({4-chloro-6-[(2-{[4-chloro-6-({4-[2-(4,8-disulfonaphthalen-2-yl)diazen-1-yl]-5-acetamido-2-methoxyphenyl}amino)-1,3,5-triazin-2-yl]amino}-5-methylphenyl)amino]-1,3,5-triazin-2-yl}amino)-2-acetamido-5-methoxyphenyl]diazen-1-yl}naphthalene-1,5-disulfonic acid; 3-{2-[4-({4-chloro-6-[(2-{[4-chloro-6-({4-[2-(4,8-disulfonaphthalen-2-yl)diazen-1-yl]-5-acetamido-2-methoxyphenyl}amino)-1,3,5-triazin-2-yl]amino}-6-methylphenyl)amino]-1,3,5-triazin-2-yl}amino)-2-acetamido-5-methoxyphenyl]diazen-1-yl}naphthalene-1,5-disulfonic acid
Constituent 1
Test animals
- Species:
- other: Rat (Wistar-derived)
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- other: Paste in minimal quantity of deionised water.
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Male: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0
Female: 2000 mg/kg bw; Number of animals: 5; Number of deaths: 0 - Gross pathology:
- Effects on organs: No treatment-related macroscopic findings were observed.
- Other findings:
- Signs of toxicity (local): No deaths and no signs of toxicity were observed. Staining of the skin by the substance was seen in most animals between day 2 and day 5, and could have obscured any slight erythema. Most animals lost weight in the first few days, but all had exceeded their initial body weight by day 8 and continued to gain weight until the end of the study.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
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