Registration Dossier
Registration Dossier
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EC number: 416-250-2 | CAS number: 84632-59-7
Endpoint summary
Administrative data
Description of key information
Additional information
Read-across justification:
Data on terrestrial toxicity of the test substance are not available. However acute data on the toxicity to soil macroorganismen and data on the toxicity to terrestrial plants are available from 2 analogous substances. Both analogue substances (EC 465-080-5 and EC 401-540-3) are also DPP-pigments. All substances share the same common functional group, the 2,5-dihydro-pyrrolo(3,4-c)pyrrole-1,4-dione core. They only differ in the moiety. The analogue substance 1 is a reaction mass and has a chlorine moiety either in ortho-, meta- or para-position of both phenyl rings instead of a tert-butyl moiety. And analogue substance 2 has a chlorine moiety in para position of both phenyl. Effects on toxicity and behavior within the environmental compartments due to the different moieties are not expected.
All substances are not readily biodegradable and due to the inert structure no break-down products will occur in any environmental compartment. Additionally, all substances have a very low solubility in water and a similar molecular weight. Due to their similar PC properties the behavior within the environmental compartments is comparable. Additional, all substances show same results in the aquatic toxicity test and no toxic effects occur within the range of solubility for all trophic levels (acute and chronic). Additionally, the terrestrial studies on both analogue substances show also no effects up to a concentration of 1000 mg/kg test substance. Since the PC properties are almost the same and also all substances show no effects up to the solubility limit neither in acute nor in chronic studies it can be expected that the results of the terrestrial studies of the two analogues substances can be used as read-across. The same results are expected for the test substance. Therefore, in overall conclusion, the read-across is justified.
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EC 416-250-2 (test substance) |
EC 465-080-5 (read-across substance 1) |
EC 401-540-3 (read-across substance 2) |
Structure (can be found in the CSR-pdf) |
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Physico-chemical data |
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Mol. weight |
400.521 |
357.2 |
357.196 |
Melting point |
>500°C |
>425°C |
> 300°C |
Relative density |
1.202 |
1.600 |
1.58 |
Water solubility (mg/L) |
< 0.1 |
< 0.5 |
< 0.499 |
LogKow |
5 |
4.5 - 4.7 |
< 3 |
Environmental fate data |
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Hydrolysis |
Not expected, low water solubility |
Not expected, low water solubility |
Not expected, low water solubility |
Biodegradation in water |
No biodegradation observed |
No biodegradation observed |
No biodegradation observed |
Bioaccumulation (OECD 305) |
BMF =0.0151 BCF < 25 |
-- |
-- |
Adsorption/desorption (logKoc) |
6.639 (calculated) |
4.95 (HPLC) |
4.1 (calculated) |
Ecotoxicity data |
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Short-term toxicity to fish (OECD 201) |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
Short-term toxicity to aquatic invertebrates (OECD 202) |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
Short-term toxicity to aquatic algae and cyanobacteria (OECD 201) |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
No acute toxic effects within the range of solubility |
Long-term toxicity to fish (OECD 204) |
-- |
-- |
No chronic toxic effects within the range of solubility |
Long-term toxicity to aquatic invertebrates (OECD 211) |
No chronic toxic effects within the range of solubility |
No chronic toxic effects within the range of solubility |
No chronic toxic effects within the range of solubility |
Toxicity to micro-organisms (OECD 209) |
EC50 > 100 mg/L |
EC50 > 100 mg/L |
EC50 > 100 mg/L |
Toxicity to soil macroorganisms (OECD 207) |
-- |
LC50 > 1000 mg/kg |
LC50 > 1000 mg/kg |
Toxicity to terrestrial plants (OECD 208) |
-- |
-- |
LC50 (emergence) > 1000 mg/kg EC50 (growth) > 1000 mg/kg |
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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