Registration Dossier
Registration Dossier
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EC number: 200-554-5 | CAS number: 63-05-8
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: published data
Data source
Reference
- Reference Type:
- publication
- Title:
- Anabolic steroid abuse causing recurrent hepatic adenomas and hemorrhage
- Author:
- Martin NM et.al.
- Year:
- 2 008
- Bibliographic source:
- World J Gastroenterol 14(28), 4573-4575
Materials and methods
- Study type:
- clinical case study
Test material
- Reference substance name:
- Androst-4-ene-3,17-dione
- EC Number:
- 200-554-5
- EC Name:
- Androst-4-ene-3,17-dione
- Cas Number:
- 63-05-8
- Molecular formula:
- C19H26O2
- IUPAC Name:
- androst-4-ene-3,17-dione
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
The authors report the case of a 27-year-old male bodybuilder with multiple hepatic adenomas induced by anabolic steroids (oral androstenedione and parenteral nandrolone). He initially presented with tumor hemorrhage and was treated with left lateral hepatic segmentectomy. Regression of the remaining tumors was observed with cessation of steroid use. However, 3 years and a half after his initial hepatic segmentectomy, he presented with recurrent tumor enlargement and intraperitoneal hemorrhage in the setting of steroid abuse relapse. This is the first reported case of hepatic adenoma regrowth with recidivistic steroid abuse, complicated by life-threatening hemorrhage.
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