Registration Dossier
Registration Dossier
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EC number: 231-831-9 | CAS number: 7758-05-6
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
Data source
Reference
- Reference Type:
- publication
- Title:
- Final Report on the Safety Assessment of Sodium Iodate
- Author:
- American College of Toxicology
- Year:
- 1 995
- Bibliographic source:
- Journal of the American College of Toxicology
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data from review article
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Sodium iodate
- EC Number:
- 231-672-5
- EC Name:
- Sodium iodate
- Cas Number:
- 7681-55-2
- IUPAC Name:
- sodium iodate
- Details on test material:
- The antimutagenic potential of 0.1 and 0.5 Fmol Sodium Iodate against 1.28 micro mol aflatoxin B, (AFB,) was examined by plate incorporation assay performed according to the method of Maron and Ames (1983) using Salmonella typhimurium strains TAl00 and TA98
Constituent 1
Method
- Target gene:
- Salmonella typhimurium strains TAl00 and TA98
Species / strainopen allclose all
- Species / strain / cell type:
- S. typhimurium TA 100
- Species / strain / cell type:
- S. typhimurium TA 98
Controls
- Positive controls:
- yes
- Remarks:
- A plate to which Sodium Iodate was not added was used as control
- Details on test system and experimental conditions:
- Triplicate plates were used, and the assay was repeated at least once
Results and discussion
Test resultsopen allclose all
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Species / strain:
- S. typhimurium TA 100
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Additional information on results:
- Sodium Iodate had antimutagenic activity toward AFB, when tested using strain TA100, but not when using strain TA98. The
ID50 (dose required to inhibit the mutagenic activity of AFB, by 50%) of Sodium Iodate using strain TAlOO was 150 nmol. - Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Sodium Iodate had antimutagenic activity toward AFB, when tested using strain TA100, but not when using strain TA98. The
ID50 (dose required to inhibit the mutagenic activity of AFB, by 50%) of Sodium Iodate using strain TAlOO was 150 nmol. - Executive summary:
Sodium Iodate showed no mutagenic activity by the Ames test. The ID50 (dose required to inhibit the mutagenic activity of AFB, by 50%) of Sodium Iodate using strain TAlOO was 150 nmol. Thus it exhibited anti-mutagenic activity
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