Registration Dossier
Registration Dossier
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EC number: 221-499-3 | CAS number: 3121-61-7
Long-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (21d) = 0.19 mg/L (measured, arithm. mean) (Daphnia magna, EPA OTS 797.1330)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.19 mg/L
Additional information
Since no data on the long-term toxicity of 2-methoxyethyl acrylate (CAS 3121-61-7) to aquatic invertebrates are available, in accordance to Regulation (EC) No. 1907/2006 Annex XI, 1.5 read-across to another structurally related analogue substance was conducted. Read-across data from ethyl acrylate (CAS 140 -88 -5) were used, which was considered suitable for read-across.
The key study was conducted with ethyl acrylate according to GLP and US EPA guideline OTS 797.1330 using Daphnia magna as test organism. Within this flow-through study, nominal test concentrations of 0.38, 0.75, 1.5, 3.0 and 6.0 mg/L were applied with corresponding mean measured concentrations of 0.19, 0.45, 0.73, 1.7 and 3.2 mg/L. These low mean measured test concentrations are considered to be due to the volatility and biodegradability of the test substance. As a result, a 21d-NOEC value of 0.19 mg/L for reproduction was determined based on measured concentrations (arithmetic mean) (ABC Laboratories, 1997).
Due to structural and property similarities with the tested analogue substance, it can be concluded that the above result also applies to 2-methoxyethyl acrylate (CAS 3121-61-7). For details see analogue justification in the overall summary of Chap 6.1 and in Chapter 13 of the Technical Dossier.
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