Methylhydrazine

Endpoint summary

Description of key information

Methylhydrazine is highly corrosive and irritating to the skin, eyes, and mucous membranes of the respiratory system in humans and animals.

Key value for chemical safety assessment

Skin irritation / corrosion

Link to relevant study records

Reference

Endpoint:

skin irritation / corrosion, other

Remarks:

general observations

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

secondary literature

Principles of method if other than guideline:

No data

GLP compliance:

not specified

Remarks on result:

probability of severe irritation

Interpretation of results:

Category 1B (corrosive) based on GHS criteria

Conclusions:

Methylhydrazine can produce severe skin and eye damage in animal models and would be expected to perform similarly in humans.

Executive summary:

Methylhydrazine can produce severe skin and eye damage in animal models and would be expected to perform similarly in humans.

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (corrosive)

Eye irritation

Link to relevant study records

Reference

Endpoint:

eye irritation: in vitro / ex vivo

Data waiving:

study scientifically not necessary / other information available

Justification for data waiving:

the study does not need to be conducted because the substance is classified as skin corrosion, leading to classification as serious eye damage (Category 1)

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Respiratory irritation

Endpoint conclusion

Endpoint conclusion:

adverse effect observed (irritating)

Additional information

According to the Office of Health and Environmental Assessment, Environmental Criteria and Assessment Office, Methylhydrazine is highly corrosive and irritating to the skin, eyes, and mucous membranes of the respiratory system in humans and animals. This was reported in a summary created in April 1992 and updated in 2000: both published literature and information obtained from Agency program office files were evaluated.

Skin corrosion, eye and respiratory irritation were also reported in HSDB (data peer-reveiwed): " Methylhydrazine can produce severe skin and eye damage in animal models and would be expected to perform similarly in humans (...) All hydrazines have similar toxic local effects due to their irritant properties. The vapor is highly irritating to the eyes, upper respiratory tract, & skin".

- Hydrazine (CAS: 302-01-2), 1,1-dimethylhydrazine (CAS: 57-14-7) and 1,2-dimethylhydrazine (CAS: 540-73-8) are all subject of a harmonized classification as Category 1B (H314).

Justification for classification or non-classification

The registered substance is proposed to be classified H314/H318 (only H314 mentioned on the labelling) according to CLP, based on:

- harmonized classification Category 1B (H314) of 3 closely related substances differing by one additional or absent methyl;

- secondary literature data on the registered substance, reporting skin corrosive effects, eye and respiratory irritation (cited by peer-reviewed sources (HSDB)).