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EC number: 481-150-8 | CAS number: 500011-86-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Well documented GLP & OECD 202 guideline study.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2006
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Deviations:
- no
- Remarks:
- The study was conducted according to the guideline in effect at time of study conduct.
- Qualifier:
- according to guideline
- Guideline:
- other: EEC (Method C.2.)
- Deviations:
- no
- Remarks:
- The study was conducted according to the guideline in effect at time of study conduct.
- GLP compliance:
- yes (incl. QA statement)
Test material
- Reference substance name:
- -
- EC Number:
- 481-150-8
- EC Name:
- -
- Cas Number:
- 500011-86-9
- Molecular formula:
- C9H5BrClN3O2
- IUPAC Name:
- 3-bromo-1-(3-chloropyridin-2-yl)-1H-pyrazole-5-carboxylic acid
- Reference substance name:
- 1H-Pyrazole-5-Carboxylic Acid, 3-Bromo-1-(3-Chloro-2-Pyridinyl)-
- IUPAC Name:
- 1H-Pyrazole-5-Carboxylic Acid, 3-Bromo-1-(3-Chloro-2-Pyridinyl)-
- Reference substance name:
- DBC 80
- IUPAC Name:
- DBC 80
- Details on test material:
- Sample Code : IN-DBC80
Empirical Formula : C9H5BrClN3O2
Molecular Weight : 302.52
Active Ingredient Content : 96.7% (purity)
Appearance : Tan colour powder
Constituent 1
Constituent 2
Constituent 3
Sampling and analysis
- Analytical monitoring:
- yes
- Details on sampling:
- Water samples were collected during the definitive experiment after 0 and 48 hours of exposure from the dilution water control, solvent control and the 120 mg/L test solution.
Test solutions
- Vehicle:
- yes
- Details on test solutions:
- Stock solution was prepared by dissolving 100 mg of the test substance in 0.08 mL acetone and the volume was made up to 100 mL using distilled water. The appropriate volumes of stock solution were transferred to the exposure medium to obtain the final desired test solution concentrations. The amount of acetone use was such that the final concentration of acetone did not exceed 0.1 mL/L in the test solutions.
Test organisms
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- The Daphnia magna were reared by IIBAT in 1000 mL bottles. Daphnia magna less than 24 hours old were removed from the culture maintained in thetest room and used for the experiment. During the experiment, daphnids were not fed. Brood daphnids were maintained and cultured in dilution water at the test temperature prior to the start of the test.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Post exposure observation period:
- N/A
Test conditions
- Hardness:
- The hardness of the dilution water (a 1:1 ratio of hard and soft water) was between 140 and 250 mg/L as CaCO3. The hardness of the control, solvent control, and 120 mg/L test solutions were 194-197 mg/L as CaCO3.
- Test temperature:
- Temperature ranged from 22.8 to 23.1°Celcius.
- pH:
- pH ranged from 7.77 to 7.86.
- Dissolved oxygen:
- Dissolved oxygen concentrations ranged from 7.57 to 7.78 mg/L.
- Nominal and measured concentrations:
- A nominal concentration of 120 mg/L was chosen for the definitive test based on the results of the preliminary range finding experiment.
Results and discussion
Effect concentrations
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 120 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- dissolved
- Basis for effect:
- mobility
- Details on results:
- No immobility or toxicity signs were observed in the daphnia from any of the test groups after 48 hours of exposure. The 48-hour EC50 was greater than 120 mg/L. The highest concentration tested causing no immobility at the test end was 120 mg/L. The lowest concentration tested causing 100% immobility at the test end was 120 mg/L.
- Reported statistics and error estimates:
- Statistical analyses were not calculated because there was 100% survival in the limit test.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- yes
- Conclusions:
- Exposure of Daphnia magna to IN-DBC80 at a concentration of 120 mg/L resulted in no immobilities or sublethal effects.
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