Registration Dossier
Registration Dossier
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EC number: 233-732-6 | CAS number: 10339-55-6
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1975, details not available
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Pre-GLP
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 975
- Report date:
- 1975
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Guideline:
- other: no indication
- Principles of method if other than guideline:
- no remarks
- GLP compliance:
- no
- Remarks:
- pre-GLP
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3,7-dimethylnona-1,6-dien-3-ol
- EC Number:
- 233-732-6
- EC Name:
- 3,7-dimethylnona-1,6-dien-3-ol
- Cas Number:
- 10339-55-6
- Molecular formula:
- C11H20O
- IUPAC Name:
- 3,7-dimethylnona-1,6-dien-3-ol
- Details on test material:
- - Name of test material (as cited in study report): 75-54, Ethyl linalool
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- No indication
Administration / exposure
- Type of coverage:
- not specified
- Vehicle:
- not specified
- Details on dermal exposure:
- Ten rabbits (age and sex not given) were treated dermally with Ethyllinalool at a dose level of 5000 mg/kg bw.
- Duration of exposure:
- no remarks
- Doses:
- 5000 mg/kg bw.
- No. of animals per sex per dose:
- 10 animals per dose (no indication about the sex)
- Control animals:
- not specified
- Details on study design:
- no remarks
- Statistics:
- no remarks
Results and discussion
- Preliminary study:
- No remarks
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Mortality:
- All rabbits survived.
- Clinical signs:
- other: No systemic signs of toxicity were seen. Skin irritation consisted of slight redness (3 of 10 animals), moderate redness (6 of 10 animals), slight edema (1 of 10 animals), and moderate edema (8 of 10 animals).
- Gross pathology:
- no remarks
- Other findings:
- no remarks
Any other information on results incl. tables
Not relevant
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- The dermal LD50 in rabbits was determined be greater than 5000 mg/kg bw.
- Executive summary:
The dermal LD50 in rabbits was determined to be greater than 5000 mg/kg bw.
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