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EC number: 234-521-1 | CAS number: 12007-89-5
Particle size distribution (Granulometry)
Administrative data
Link to relevant study record(s)
- Endpoint:
- particle size distribution (granulometry)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: GLP study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 110 (Particle Size Distribution / Fibre Length and Diameter Distributions)
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: BS ISO 13320-1:1999
- Deviations:
- not specified
- Qualifier:
- according to guideline
- Guideline:
- other: CIPAC MT 187
- Deviations:
- not specified
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- Laser scattering/diffraction
- Type of distribution:
- other: Laser diffraction
- Mass median aerodynamic diameter:
- 75.259 µm
- Geometric standard deviation:
- 3.588
- Percentile:
- D10
- Mean:
- 11.892 µm
- Remarks on result:
- other: 0.54 % STDV
- Percentile:
- D50
- Mean:
- 60.064 µm
- Remarks on result:
- other: 1.20 % STDV
- Percentile:
- D90
- Mean:
- 184.771 µm
- Remarks on result:
- other: 1.01 % STDV
- Conclusions:
- 7.78 % by volume of sample was seen to be < 10.00 μm.
D50 = 60.064 µm - Executive summary:
The test substance was assessed for particle size distribution in a GLP study (2010) according to OECD Guideline 110, CIPAC Method MT 187 and BS ISO 13320-1:1999. The d50 was 60.064 μm. 7.78 % by volume of sample was seen to be < 10.00 μm. Coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %. Thus repeatibility of the characteristic particles in the size distribution are within the acceptable limits as per the BS ISO 13320-1 test standard.
Reference
The particle size was analysed over the range 0.02 to 2000μm.
Full test results:
|
Run 1 |
Run 2 |
Run 3 |
Run 4 |
Run 5 |
** Average |
Volume weighted mean |
81.273 |
82.203 |
79.653 |
81.327 |
80.563 |
81.004 |
Median (d50) |
60.003 |
60.923 |
58.818 |
60.621 |
59.995 |
60.064 |
Mode (μm) |
103.568 |
108.776 |
102.165 |
108.915 |
104.519 |
105.386 |
*MMAD |
75.184 |
76.336 |
73.699 |
75.957 |
75.174 |
75.259 |
10 % of material is > |
11.817 |
11.951 |
11.810 |
11.941 |
11.942 |
11.892 |
50 % of material is > |
60.003 |
60.923 |
58.818 |
60.621 |
59.995 |
60.064 |
90 % of material is > |
184.522 |
187.880 |
182.302 |
185.435 |
183.639 |
184.771 |
All results are in μm.
* Mean Mass Aerodynamic Diameter
** Average result is calculated from the entirety of the data captured in each run and is not a simple arithmetic mean.
7.78 % by volume of sample was seen to be < 10μm.
Standard deviation results:
Run No. |
1 |
2 |
3 |
4 |
5 |
STDVP |
% STDV |
d10 |
11.817 |
11.951 |
11.810 |
11.941 |
11.942 |
0.06 |
0.54 |
d50 |
60.003 |
60.923 |
58.818 |
60.621 |
59.995 |
0.72 |
1.20 |
d90 |
184.522 |
187.880 |
182.302 |
185.435 |
183.639 |
1.87 |
1.01 |
d15.78 |
16.61 |
16.85 |
16.61 |
16.83 |
16.81 |
0.11 |
0.65 |
GSD |
3.612 |
3.616 |
3.541 |
3.602 |
3.569 |
0.03 |
0.80 |
MMAD |
75.184 |
76.336 |
73.699 |
75.957 |
75.174 |
0.90 |
1.20 |
GSD = Geometric standard deviation
Coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %. Thus repeatibility of the characteristic particles in the size distribution are within the acceptable limits as per the BS ISO 13320-1 test standard.
Description of key information
The test substance was assessed for particle size distribution in a GLP study (2010) according to OECD Guideline 110, CIPAC Method MT 187 and BS ISO 13320-1:1999. The d50 was 60.064 μm. 7.78 % by volume of sample was seen to be < 10.00 μm. Coefficient of variation for d50 is less than 3 %; d10 and d90 are less than 5 %. Thus repeatability of the characteristic particles in the size distribution are within the acceptable limits as per the BS ISO 13320-1 test standard.
Additional information
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