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Diss Factsheets
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EC number: 481-670-5 | CAS number: 848301-66-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Bioaccumulation: aquatic / sediment
Administrative data
- Endpoint:
- bioaccumulation: aquatic / sediment
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: scientifically acceptable method
Data source
Reference
- Reference Type:
- other: review
- Title:
- Unnamed
- Year:
- 2 006
Materials and methods
Test guideline
- Qualifier:
- no guideline required
- Deviations:
- not applicable
- Principles of method if other than guideline:
- For the estimation/calculation the percentages by weight and the mean percentages of branching have been used to determine a composition of a typical sample of the substance. Branched and linear aliphatic components are present in a ratio that can vary between the approximate limits of 20:80 and 80:20. This compositions have been used as the basis for modelling bioaccumulation.
- GLP compliance:
- no
- Remarks:
- not applicable (QSAR calculation)
Test material
- Reference substance name:
- -
- EC Number:
- 481-670-5
- EC Name:
- -
- Cas Number:
- 848301-66-6
- Molecular formula:
- As the substance is a UVCB substance neither a molecular formular nor the molecular weight can be defined.
- IUPAC Name:
- C8-C16 branched and linear hydrocarbons (full range) – Kerosine
- Details on test material:
- - Name of test material (as cited in study report): Kerosine (Fischer-Tropsch), full range, C8-16 - branched and linear
Constituent 1
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
not applicable (QSAR calculation) - Radiolabelling:
- no
Sampling and analysis
- Details on sampling:
- not applicable (QSAR calculation)
Test solutions
- Details on preparation of test solutions, spiked fish food or sediment:
- not applicable (QSAR calculation)
Test organisms
- Test organisms (species):
- other: not applicable (QSAR calculation)
- Details on test organisms:
- not applicable (QSAR calculation)
Study design
- Route of exposure:
- other: not applicable (QSAR calculation)
- Test type:
- other: not applicable (QSAR calculation)
- Water / sediment media type:
- not specified
Test conditions
- Hardness:
- not applicable (QSAR calculation)
- Test temperature:
- not applicable (QSAR calculation)
- pH:
- not applicable (QSAR calculation)
- Dissolved oxygen:
- not applicable (QSAR calculation)
- TOC:
- not applicable (QSAR calculation)
- Salinity:
- not applicable (QSAR calculation)
- Details on test conditions:
- not applicable (QSAR calculation)
- Nominal and measured concentrations:
- not applicable (QSAR calculation)
- Reference substance (positive control):
- not required
- Remarks:
- not applicable (QSAR calculation)
- Details on estimation of bioconcentration:
- not applicable (QSAR calculation)
Results and discussion
Lipid content
- Remarks on result:
- other: not applicable (QSAR calculation)
Bioaccumulation factor
- Type:
- BCF
- Value:
- >= 634 - <= 2 563
- Remarks on result:
- other: QSAR calculation
- Details on kinetic parameters:
- not applicable (QSAR calculation)
- Metabolites:
- not applicable (QSAR calculation)
- Results with reference substance (positive control):
- not applicable (QSAR calculation)
- Details on results:
- not applicable (QSAR calculation)
- Reported statistics:
- not applicable (QSAR calculation)
Any other information on results incl. tables
In the range C5-11 the following expression is used:
log BCF = -2.66 + 0.83 (Carbon Number) – 0.0023 (Carbon Number ^ 3)
For higher carbon numbers, it should be assumed that a plateau is reached. The maximum value obtained using the QSAR model is for C11, therefore the log BCF value of 3.4 calculated for C11 also applies for all substances >C11 as a worst-case interpretation. As carbon number increases, at some point it is expected that molecular size and decreased water solubility would limit bioavailability. Thus, significantbioaccumulation would no longer take place. The molecular size at which this would occur is not known, although it has been discussed extensively in the literature and so is not discussed fully here. Molecular weights greater than 500 – 700 are considered to be too high for significant bioavailability, as mentioned in REACH Technical Guidance Chapter R11.
As shown in Table 1 the cubic model QSAR, with a maximum value used for substances with carbon number >C11, suggests that there can be B constituents in Fischer-Tropsch substances with carbon numbers >C9. There are no vB constituents.
Table 1: Predicted BCF values and interpretation of assessment of bioaccumulation
Carbon number |
C^3 |
log BCF (predicted - QSAR) |
BCF (predicted - QSAR) |
B/vB |
5 |
125 |
1.20 |
16 |
Not B |
6 |
216 |
1.82 |
67 |
Not B |
7 |
343 |
2.36 |
230 |
Not B |
8 |
512 |
2.80 |
634 |
Not B |
9 |
729 |
3.13 |
1359 |
Not B |
10 |
1000 |
3.34 |
2188 |
B |
11 |
1331 |
3.41 |
2563 |
B |
>11-approx C40 |
1728 |
3.41 |
2563(1) |
B |
(1) This represents a worst case scenario.
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Remarks:
- QSAR calculation
- Conclusions:
- It is concluded from the obtained results that the test substance 'Kerosine (Fischer-Tropsch), full range, C8-16 - branched and linear' will contain components with the potential to bioaccumulate. However, the bioconcentration factors (BCF) should be considered carefully since bioaccumulation potential may not be realised in-vivo because of the high degradability potential of the hydrocarbon components.
- Executive summary:
Bioaccumulation of 'Kerosine (Fischer-Tropsch), full range, C8-16 - branched and linear' was estimated by QSAR calculation. It is concluded from the obtained results that the test substance will contain components with the potential to bioaccumulate.
However, the BCFs should be considered carefully since bioaccumulation potential may not be realised in-vivo because of the high degradability potential of the hydrocarbon components.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.