Registration Dossier
Registration Dossier
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EC number: 605-830-2 | CAS number: 178671-69-7
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
In an Ames test performed according to OECD test guideline No. 471 and in compliance with GLP, the test article was assessed for its mutagenic potential based on the ability to induce point mutations in selected loci of several bacterial strains in a reverse mutation assay (BASF, 1998). The following strains were tested: TA 1535, TA 100, TA 1537, TA 98 and E. col i WP2 uvrA. Two plating methods, the standard plate test and the preincubation test, each in the presence and absence of a metabolic activating system (rat liver S9 mix), were employed. The test substance was found to be precipitating at concentrations of 2500 µg/plate onward. A bacteriotoxic effect was observed under all test conditions. An increase in the number of his+ or trp+ revertants was not observed in the standard plate test or in the preincubation test either without S-9 mix or after the addition of a metabolizing system. Therefore, the test substance is not considered to be mutagenic in the Salmonella typhimurium/Escherichia coli reverse mutation assay.
Short description of key information:
The test substance did not show any mutagenic potential in an Ames test.
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
Dangerous Substance Directive (67/548/EEC)
-No classification for genetic toxicity required
Classification, Labeling, and Packaging Regulation (EC) No. 1272/2008 (last amended by EC/286/2008 (2011-03-10)):
-No classification for genetic toxicity required
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