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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Endpoint:
short-term toxicity to fish
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Guideline- and GLP-Study. No certificate of analysis was submitted to test facility. No determination of the real concentrations, only nominal.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1995

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 203 (Fish, Acute Toxicity Test)
Qualifier:
according to guideline
Guideline:
EU Method C.1 (Acute Toxicity for Fish)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Reference substance name:
1,8-Naphtostyril
IUPAC Name:
1,8-Naphtostyril

Sampling and analysis

Analytical monitoring:
no

Test solutions

Vehicle:
no

Test organisms

Test organisms (species):
Danio rerio (previous name: Brachydanio rerio)
Details on test organisms:
TEST ORGANISM
- Common name: Zebrabärbling
- Source: Leine-Zoo, Laatzen
- Feeding during test: no

ACCLIMATION
- Acclimation period: min. 12 d
- Acclimation conditions (same as test or not): yes
- Food type: Kronen Fish allround 2, Fa. Ssniff
- Amount: 4 % of fish weight
- Frequency: 3 per week
- Health during acclimation (any mortality observed): mortality < 5%

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
96 h

Test conditions

Hardness:
115 mg/l CaCO3
Test temperature:
23-24,8°C
pH:
7.87-8.05
Dissolved oxygen:
87-96%
Nominal and measured concentrations:
1.0, 1.8, 3.2, 5.8, 10 mg/l
Reference substance (positive control):
not required

Results and discussion

Effect concentrationsopen allclose all
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
4.31 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC100
Effect conc.:
5.8 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
LC0
Effect conc.:
3.2 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)
Duration:
96 h
Dose descriptor:
NOEC
Effect conc.:
1 mg/L
Nominal / measured:
nominal
Conc. based on:
test mat.
Basis for effect:
mortality (fish)

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
Substance fulfills the criteria for a classification as toxic for aquatic life. Based on the datas and considering that the substance is not readily
biodegradable the classification according EU 1272/2008 as aquat. chron. 2, H411 and N, R51/53 according to 67/548/EWG is justifiable.