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EC number: 806-919-0 | CAS number: 1356964-77-6
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The 96-hour LC50 value for fathead minnows was >7.5 mg/L, the highest concentration tested. The 96-hour LC0 and the NOEC were 7.5 mg/L.
Key value for chemical safety assessment
Additional information
In a study performed according to OECD TG 203 and EPA OPPTS 850.1075 [Brougher et al, 2014] fathead minnows were exposed to a geometric series of five test concentrations, a negative control (dilution water) and a solvent control (0.1 mL/L dimethylformamide) for 96 hours under flow-through conditions. Two replicate test chambers were maintained in each treatment and control group, with 10 fish in each test chamber, for a total of 20 fish per concentration. Nominal test concentrations selected were 0.50, 1.0, 2.0, 4.0 and 8.0 mg/L. Mean measured test concentrations were determined from samples of test water collected from each treatment and control group at the beginning, the approximate mid-point and the end of the test. The mean measured test concentrations for this study were 0.40, 0.77, 1.9, 3.8 and 7.5 mg/L, representing 80, 77, 95, 95 and 94% of nominal concentrations, respectively. The results of the study were based on the mean measured concentrations. All fathead minnows in the negative and solvent control groups and all treatment groups appeared normal throughout the test, with no mortalities or overt signs of toxicity observed. The LC0 and the NOEC were 7.5 mg/L. The LC50 value at 96 hours was estimated to be >7.5 mg/L, the highest concentration tested.
The results of this study are supported by the results of a study performed according to OECD TG 203 using the read-across substance N,N-dimethyldecan-1 -amide, mixture with N,N-dimethyloctan-1 -amide (CAS No. 67359-57-3) [Zok & Yung, 1993]. In this study, Brachydanio rerio were exposed for 96h in a static system. Based on information from pre-experiments, two test substance concentrations were used. Agreement of nominal and measured concentration was verified analytically. All validity criteria were met. An acute fish toxicity LC50 (96h) of 14.8 mg/L was determined.
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