Registration Dossier
Registration Dossier
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EC number: 226-887-6 | CAS number: 5534-13-4
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 2014
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: This study is classified as reliable with restrictions because it is an acceptable and reliable study carried out by the degradation pathway. Meets generally accepted scientific principles, acceptable for assessment.
Data source
Reference
- Reference Type:
- publication
- Title:
- Acute toxicity and subacute subcutaneous toxicity studies of betamethasone derivatives.
- Author:
- Izuhara, K.
- Year:
- 1 973
- Bibliographic source:
- (Shikoku Igaku Zasshi. Shikoku Medical Journal) Shiroku Acta Medica, 29, 153-179
- Report date:
- 1973
Materials and methods
- Principles of method if other than guideline:
- Read-across from category member
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)
- EC Number:
- 227-005-2
- EC Name:
- 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 17,21-di(propionate)
- Cas Number:
- 5593-20-4
- IUPAC Name:
- 9-fluoro-11-hydroxy-16-methyl-3,20-dioxopregna-1,4-diene-17,21-diyl dipropanoate
Constituent 1
Test animals
- Species:
- rat
Administration / exposure
- Route of administration:
- oral: unspecified
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 4 000 mg/kg bw
Applicant's summary and conclusion
- Interpretation of results:
- practically nontoxic
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Not acute toxicant by oral route.
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