Registration Dossier
Registration Dossier
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EC number: 482-220-0 | CAS number: 848301-69-9
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not sensitising)
- Additional information:
The study was performed to assess the contact sensitisation potential of the test material in the albino guinea pig. The method was designed to meet the requirements of OECD Guideline No. 406 "Skin Sensitisation" and Method B6 Acute Toxicity (Skin sensitisation) of Commission Directive 96/54/EC.
The concentrations of test material for the topical induction and topical challenge phases were selected as:
Intradermal Induction: 100%
Topical Induction: 100%
Topical Challenge: 100% and 50% in liquid paraffin.
Skin Reactions Observed After Topical Challenge
100%
No skin reactions were noted at the topical challenge site of the test or control group animals at the 24 and 48 -hour observations.
50% in liquid paraffin
No skin reactions were noted at the topical challenge site of the test or control group animals at the 24 and 48 -hour observations.
The test material produced a 0% sensitisation rate.
Migrated from Short description of key information:
Under the conditions of the test, the test material produced a 0% sensitisation rate and was classified as a non-sensitiser to guinea pig skin.
Justification for classification or non-classification
Skin Sensitisation:
Under the conditions of the test, the test material produced a 0% sensitisation rate and was classified as a non-sensitiser to guinea pig skin. The test material did not meet the criteria for classification as a sensitiser according to Regulation 1272/2008/EC.
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