Dibutyl ether

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Study period:

1954

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Well performed study, study performance before implementation of GLP, purity of test item not reported.

Cross-reference

Cross-reference 1

Reason / purpose for cross-reference:

reference to same study

Cross-reference 2

Reason / purpose for cross-reference:

reference to other study

Data source

Reference

Reference Type:

publication

Title:

Range-finding toxicity data, List V

Author:

Smyth, H.F., Carpenter, C.P., Weil, C.S., Pozzani, U.C.

Year:

1954

Bibliographic source:

Arch. Ind. Hyg|Occup. Med., 10, 61-68

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

not applicable

GLP compliance:

no

Test type:

standard acute method

Test material

Test material information

Constituent 1

Reference substance name:

Dibutyl ether

EC Number:

205-575-3

EC Name:

Dibutyl ether

Cas Number:

142-96-1

Molecular formula:

C8H18O

IUPAC Name:

1-butoxybutane

Details on test material:

dibutyl ether (purity not indicated)

Test animals

Species:

rat

Strain:

Wistar

Sex:

male

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: raised at Mellon Institute of Industrial Research
- Age at study initiation: young adults
- Weight at study initiation: 90-120 grams

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

not specified

Details on oral exposure:

Single exposure

Doses:

other

No. of animals per sex per dose:

5

Control animals:

no

Details on study design:

- Duration of observation period following administration: 14 days
- The tested chemicals were diluted with water, corn oil, or a 1 % solution of sodium 3,9-diethyl-6-tridecanol sulfate (Tergitol Penetrant 7) when
necessary to bring the volume given to one rat to between 1 and 10 ml. However, it is unknown which (if any) solvent and at which concentration was used in the case of dibutyl ether.

Statistics:

The most probable LD50 value and its fiducial range were estimated by the method of Thompson (1947) using the tables of Weil (1952).

Results and discussion

Preliminary study:

not applicable

Effect levels

Sex:

male

Dose descriptor:

LD50

Effect level:

7 400 mg/kg bw

Based on:

test mat.

95% CL:

> 6 410 - < 8 530

Mortality:

no information available

Clinical signs:

other: no information available

Gross pathology:

no information available

Other findings:

no information available

Any other information on results incl. tables

None

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

Under the conditions of the study, the acute oral LD50 of dibutyl ether is 7400 mg/kg body weight with 95% CL ranging between 6410 - 8530 mg/kg body weight and will not be classified.

Executive summary:

In this study, single dose oral toxicity for rats was estimated by intubation of dosages in a logarithmic series to groups of five male Carworth-Wistar rats (90 to 120 g), raised at the Mellon Institute of Industrial Research, University of Pittsburgh, USA. The tested chemicals were diluted with water, corn oil, or a 1 % solution of sodium 3,9-diethyl-6-tridecanol sulfate (Tergitol Penetrant 7) when necessary to bring the volume given to one rat to between 1 and 10 ml. However, it is unknown which (if any) solvent and at which concentration was used in the case of dibutyl ether. Fourteen days after dosing, mortality was considered complete. The most probable LD50 value and its fiducial range were estimated by the method of Thompson (1947) using the tables of Weil (1952). Clinical signs were not reported. Under the conditions of the study, the acute oral LD50 of dibutyl ether is 7400 mg/kg body weight with 95% CL ranging between 6410 - 8530 mg/kg body weight and will not be classified.