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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Effects on fertility

Effect on fertility: via oral route
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Additional information

There are no reproductive toxicity data on 3 -(trichlorosilyl)propionitrile or its hydrolysis product, 3 -propanenitrilesilanetriol, so good quality data for the related substance 3 -(triethoxysilyly)propionitrile have been used to assess the reproductive toxicity of

3 -(trichlorosilyl)propionitrile.

3 -(trichlorosilyl)propionitrile hydrolyses rapidly in contact with water (half-life <1 second at pH 7), generating HCl and 3 -propanenitrilesilanetriol. 3 -(Triethoxysilyl)propionitrile (CAS 919 -31 -3) hydrolyses more slowly at pH 7 (half-life ca. 7 hours), but under acidic conditions such as in the stomach following ingestion, much more rapid hydrolysis can be expected based on experience with other ethoxysilanes. The relevant hydrolysis products are ethanol and 3 -propanenitrilesilanetriol Both parent materials therefore generate a common silanol hydrolysis product. At the doses levels and those relevant for human exposure, ethanol generated by hydrolysis in the stomach would not be expected to contribute any reproductive toxicity effects. It is therefore considered appropriate to read-across the results of the oral OECD 422 study on CAS 919 -31 -3.


Short description of key information:
No reproductive toxicity data are available for 3-(trichlorosilyl)propionitrile, therefore good quality data for the related substance 3-(triethoxysilyl)propionitrile have been read-across.
No treatment-related effects were observed in any of the reproductive parameters evaluated in an oral OECD 422 study in rats. Based on the results of this screening study, the NOAEL for reproductive toxicity of 3-(triethoxysilyl)propanenitrile in the rat via oral dosing was determined to be 1000
mg/kg bw/day.

Effects on developmental toxicity

Description of key information
No developmental toxicity data are available for 3-(trichlorosilyl)propionitrile, therefore good quality data for the related substance 3-(triethoxysilyl)propionitrile have been read-across.
No treatment-related effects were observed in any of the developmental parameters evaluated in an oral OECD 422 study in rats. Based on the results of this screening study, the NOAEL for reproductive toxicity of 3-(triethoxysilyl)propanenitrile in the rat via  oral dosing was determined to be 1000 
mg/kg bw/day.
Effect on developmental toxicity: via oral route
Dose descriptor:
NOAEL
1 000 mg/kg bw/day
Additional information

There are no developmental toxicity data on 3 -(trichlorosilyl)propionitrile or its hydrolysis product, 3 -propanenitrilesilanetriol, so good quality data for the related substance 3 -(triethoxysilyly)propionitrile have been used to assess the developmental toxicity of

3 -(trichlorosilyl)propionitrile.

3 -(trichlorosilyl)propionitrile hydrolyses rapidly in contact with water (half-life <1 second at pH 7), generating HCl and 3 -propanenitrilesilanetriol. 3 -(Triethoxysilyl)propionitrile (CAS 919 -31 -3) hydrolyses more slowly at pH 7 (half-life ca. 7 hours), but under acidic conditions such as in the stomach following ingestion, much more rapid hydrolysis can be expected based on experience with other ethoxysilanes. The relevant hydrolysis products are ethanol and 3 -propanenitrilesilanetriol Both parent materials therefore generate a common silanol hydrolysis product. At the doses levels and those relevant for human exposure, ethanol generated by hydrolysis in the stomach would not be expected to contribute any developmental toxicity effects. It is therefore considered appropriate to read-across the results of the oral OECD 422 study on CAS 919 -31 -3.

Justification for classification or non-classification

There are no data to suggest that 3-(trichlorosilyl)propiononitrile should be classified for reproductive or developmental toxicity.

Additional information