Registration Dossier
Registration Dossier
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EC number: 938-925-5 | CAS number: -
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study was performed according to the EU Method A8. No data on GLP.
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient)
- Deviations:
- no
- GLP compliance:
- not specified
- Type of method:
- shake-flask method to: flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- gas chromatography
- Type:
- log Pow
- Partition coefficient:
- 3.83
- Temp.:
- 22.5 °C
- Remarks on result:
- other: pH not reported
- Conclusions:
- Partition Coefficient of the test material determined at 22,5 ± 1,0 °C was 3,83 (± 0,31)
- Executive summary:
The determination of partition coefficient 1-octanol/water was carried out according to the EU Method A.8 (Shake-flask Method), with GLP.
Duplicate determinations were made under three different test conditions, in the first, the calculated volume ratio of n-octanol to water is used; in the second this ratio is divided by two; and in the third, this ratio is multiplied by two.
The repeatability is in a range below ± 0,3 log units.The Partition Coefficient of the test material determined at 22,5 ± 1,0 °C was 3,83 (± 0,31)
Reference
Table 1. log pow Weighted Average for all Test
Test |
Volume of aqueous phase (l) |
Co/Cw |
log Pow |
log Pow Average for each Test |
log PowWeighted Average for all Test |
C-l |
0,505 |
8523 |
3.93 |
4,05 |
3,83 ±0,31 |
C-2 |
0,506 |
28138 |
4.45 |
||
A-1 |
0,252 |
16296 |
4.21 |
4,19 |
|
A-2 |
0,253 |
15153 |
4.18 |
||
B-1 |
0,127 |
3026 |
3.48 |
3,50 |
|
B-2 |
0,127 |
3212 |
3.51 |
Description of key information
Key study: Experimental results: EU A.8. No data on GLP. The partition coefficient of the test substance was 3.83 at 22.5 ºC.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- 3.83
- at the temperature of:
- 22.5 °C
Additional information
Key study: Experimental result on test item Reaction products of n-octanol and acrylic acid, first distillation pitch:
The partition coefficient of the substance was carried out according to the EU Method A.8 and was established to be 3.83 at 22.5 ºC.
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