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Diss Factsheets

Environmental fate & pathways

Hydrolysis

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Administrative data

Link to relevant study record(s)

Reference
Endpoint:
hydrolysis
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
guideline study
Qualifier:
according to guideline
Guideline:
EU Method C.7 (Degradation: Abiotic Degradation: Hydrolysis as a Function of pH)
GLP compliance:
yes
Radiolabelling:
no
Analytical monitoring:
yes
Buffers:
- at pH value 9: borax / hydrochloric acid, Riedel de Haen Art. No. 33548, ready to use solution
- at pH value 7: potassium dihydrogen phosphate/ Di-sodium hydrogen phosphate, Riedel de Haen Art. No. 33546, ready to use solution
- at pH value 4: citric acid/ potassium hydroxide/ sodium chloride, Riedel de Haen Art. No. 33543, ready to use solution
Estimation method (if used):
Half-time and the rate constant (first order reaction) at 25 °C were estimated according to the Arrhenius equation.
The calculation of the half times and the reaction rate constants were based on linear regression (Inc versus t and Ink versus T 1 respectively) following the first order concentration-time-law.
Details on test conditions:
The substance was examined in each case at pH 4, 7 and 9. The test temperature was 50 °C, 65 °C and 80 °C at pH 9 and pH 7 and 50 °C at pH 4.
Duration:
2 h
pH:
4
Temp.:
50 °C
Initial conc. measured:
100 other: %
Duration:
261 h
pH:
7
Temp.:
50 °C
Initial conc. measured:
100 other: %
Duration:
91 h
pH:
7
Temp.:
65 °C
Initial conc. measured:
100 other: %
Duration:
8.7 h
pH:
7
Temp.:
80 °C
Initial conc. measured:
100 other: %
Duration:
261 h
pH:
9
Temp.:
50 °C
Initial conc. measured:
100 other: %
Duration:
90.7 h
pH:
9
Temp.:
65 °C
Initial conc. measured:
100 other: %
Duration:
9.1 h
pH:
9
Temp.:
80 °C
Initial conc. measured:
100 other: %
Preliminary study:
At pH value = 9 and 50 °C:
preliminary test (test 1):
The degradation reaction is given by pseudo-first order reaction (correlation coefficient 0.99752), the half-time and the rate constant ( first order reaction) is given by: t(1/2) = 311 hours, k = 2.21035E-08 /s

At pH value = 7 and 50 °C:
preliminary test (test 1):
The degradation re-action is given by pseudo-first order reaction (correlation coefficient 0.99193), the half-time and the rate constant ( first order reaction) is given by: t(1/2) = 239 hours, k = 8.05061E-07 /s

At pH value = 4 and 50 °C:
preliminary test (test 1):
The degradation reaction is given by pseudo-first order reaction (correlation coefficient 0.99979), the half-time and the rate constant ( first order reaction) is given by: t(1/2) = 1.27 hours, k= 1.51138E-04 /s
Transformation products:
not measured
% Recovery:
34.6
pH:
4
Temp.:
50 °C
Duration:
2 h
% Recovery:
44.9
pH:
7
Temp.:
50 °C
Duration:
261 h
% Recovery:
49.2
pH:
7
Temp.:
65 °C
Duration:
91 h
% Recovery:
58.9
pH:
7
Temp.:
80 °C
Duration:
8.7 h
% Recovery:
55.5
pH:
9
Temp.:
50 °C
Duration:
261 h
% Recovery:
56.2
pH:
9
Temp.:
65 °C
Duration:
90.7 h
% Recovery:
59.5
pH:
9
Temp.:
80 °C
Duration:
9.1 h
Key result
pH:
7
Temp.:
25 °C
Hydrolysis rate constant:
0 s-1
DT50:
6 022 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: calculated according to Arrhenius equation
Key result
pH:
9
Temp.:
25 °C
Hydrolysis rate constant:
0 s-1
DT50:
8 711 h
Type:
(pseudo-)first order (= half-life)
Remarks on result:
other: calculated according to Arrhenius equation
pH:
9
Temp.:
50 °C
Hydrolysis rate constant:
0 s-1
DT50:
311 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
65 °C
Hydrolysis rate constant:
0 s-1
DT50:
109 h
Type:
(pseudo-)first order (= half-life)
pH:
9
Temp.:
80 °C
Hydrolysis rate constant:
0 s-1
DT50:
12.7 h
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
50 °C
Hydrolysis rate constant:
0 s-1
DT50:
239 h
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
65 °C
Hydrolysis rate constant:
0 s-1
DT50:
88.9 h
Type:
(pseudo-)first order (= half-life)
pH:
7
Temp.:
80 °C
Hydrolysis rate constant:
0 s-1
DT50:
10.9 h
Type:
(pseudo-)first order (= half-life)
pH:
4
Temp.:
50 °C
Hydrolysis rate constant:
0.001 s-1
DT50:
1.27 h
Type:
(pseudo-)first order (= half-life)
Validity criteria fulfilled:
yes
Conclusions:
The substance is degradable at pH 9, pH 7 and pH 4. The half-lives (t1/2) for the hydrolytic dissimilation calculated for 25 °C were 6022 hours for pH 7 and 8711 hours at pH9. At pH4 and 50°C a half-life of 1.27 h was determined.
Executive summary:

The substance is degradable according to EG guideline C.7 92/69 at pH 9, pH 7 and pH 4. The calculation of the half times and the reaction rate constants were based on linear regression following the first order concentration-time-law.

The half-lives (t1/2) for the hydrolytic dissimilation calculated for 25°C were 6022 hours for pH 7 and 8711 hours for pH 9. At pH 4 and 50°C a fast degradation of the test substance was observed within a short time (1.27 hours).

Description of key information

The substance is degradable according to EG guideline C.7 92/69 at pH 9, pH 7 and pH 4. The calculation of the half times and the reaction rate constants were based on linear regression following the first order concentration-time-law.

The half-lives (t1/2) for the hydrolytic dissimilation calculated for 25°C were 6022 hours for pH 7 and 8711 hours for pH 9. At pH 4 and50°C a fast degradation of the test substance was observed within a short time (1.27 hours).

Key value for chemical safety assessment

Half-life for hydrolysis:
6 022 h
at the temperature of:
25 °C

Additional information