Registration Dossier
Registration Dossier
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EC number: 228-391-5 | CAS number: 6258-06-6
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Secondary Source, full report not available for review
Data source
Referenceopen allclose all
- Reference Type:
- secondary source
- Title:
- Unnamed
- Year:
- 1 992
- Report date:
- 1992
- Reference Type:
- publication
- Title:
- Toxicity and ecotoxicity of sulfonic acids: structure-activity relationship
- Author:
- Greim H et al.
- Year:
- 1 994
- Bibliographic source:
- Chemosphere Vol. 28, No. 12, pp. 2203-2236
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: EU guideline 84/449/EWG, Annex V, B.7
- GLP compliance:
- yes
Test material
- Reference substance name:
- Sodium 1-amino-4-bromo-9,10-dioxoanthracene-2-sulphonate
- EC Number:
- 228-391-5
- EC Name:
- Sodium 1-amino-4-bromo-9,10-dioxoanthracene-2-sulphonate
- Cas Number:
- 6258-06-6
- Molecular formula:
- C14H8BrNO5S.Na
- IUPAC Name:
- sodium 1-amino-4-bromo-9,10-dioxo-9,10-dihydroanthracene-2-sulfonate
- Details on test material:
- no data
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- other: demineralized water
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 28 days
- Frequency of treatment:
- daily; 7 d/week
Doses / concentrations
- Remarks:
- Doses / Concentrations:
40, 200, 1000 mg/kg bw/day
Basis:
actual ingested
- No. of animals per sex per dose:
- 5
- Control animals:
- yes, concurrent vehicle
- Details on study design:
- - Post exposure period: No
Examinations
- Observations and examinations performed and frequency:
- no data
- Sacrifice and pathology:
- no data
- Statistics:
- no data
Results and discussion
Results of examinations
- Details on results:
- 200 mg, male: slight hepatocytomegaly, hyaline droplets and intraepithelial eosinophilic cytoplasmic inclusions in the tubulus epithelium
1000 mg, male/female: reduced weight gain, reduced food intake, reduced erythrocyte count, reduced hemoglobin and hematocrit content, increased spleen weight, congestion, increased extramedullary hematopoiesis.
No further information was given.
Effect levels
open allclose all
- Dose descriptor:
- NOEL
- Effect level:
- 40 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male
- Basis for effect level:
- other: see 'Remark'
- Dose descriptor:
- NOEL
- Effect level:
- 200 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- female
- Basis for effect level:
- other: 1000 mg, female: reduced weight gain, reduced food intake, reduced erythrocyte count, reduced hemoglobin and hematocrit content, increased spleen weight, congestion, increased extramedullary hematopoiesis.
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
