Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 642-362-8 | CAS number: 1190630-03-5
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
Description of key information
Ziegler Bottoms are characterized as comprising of two primary constituents; icosan-1-ol and docosan-1-ol. In accordance with Column 2 of REACH Annex VIII, the activated sludge respiration inhibition study (required in Section 9.1.4) does not need to be conducted as the substance is readily biodegradable and the applied test concentrations are in the range that can be expected in the influent to a sewage treatment plant.
Key value for chemical safety assessment
Additional information
Ziegler Bottoms are characterized as comprising of two primary constituents; icosan-1-ol and docosan-1-ol. Together these constituents represent a structural class of components (alcohols) that constitute approximately 82% of the composition of Ziegler Bottoms. Study data, where available, for each of these primary constituents has been evaluated and considered together. In a conservative approach the most sensitive study result from across the two primary constituents has been identified and used to adequately address the Ziegler Bottoms endpoint in question.
In accordance with Column 2 of REACH Annex VIII, the activated sludge respiration inhibition study (required in Section 9.1.4) does not need to be conducted as the substance is readily biodegradable as detailed below and the applied test concentrations are in the range that can be expected in the influent to a sewage treatment plant.
Biodegradation
Icosan-1-ol and docosan-1-ol are both readily biodegradable. The most recent reliable study (OECD 301B) using icosan-1-ol reported results of 87.9% (CO2) in 28 days confirming the readily biodegradable (P&G, 2009). The finding is consistent with very high levels of removal in other types of test systems where very fast degradation and metabolism in microorganisms and a range of trophic levels has been identified for alcohols in the range C6-24. Ready biodegradability means that the test substance will rapidly be unavailable for uptake and bioaccumulation in biological organisms.
In summary, the data requirement for microorganism studies is waived on the evidence of ready biodegradability and the applied test concentrations are in the range that can be expected in the influent to a sewage treatment plant.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
