Registration Dossier
Registration Dossier
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EC number: 430-610-6 | CAS number: 226996-19-6
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: OECD 403 (1981)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Details on test material:
- Physical form of substance: S
Constituent 1
Test animals
- Species:
- other: rat, Wistar (SPF)
Administration / exposure
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- nose only
- Details on inhalation exposure:
- Nose only
- Analytical verification of test atmosphere concentrations:
- no
- Duration of exposure:
- 4 h
- Concentrations:
- 5000 mg/m3
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- > 5.31 mg/L air
- Exp. duration:
- 4 h
- Mortality:
- Male: 5.31 mg/L; Number of animals: 5; Number of deaths: 1
Female: 5.31 mg/L; Number of animals: 5; Number of deaths: 0 - Clinical signs:
- other: Signs of toxicity related to dose levels: One male was found dead after 1 day. No other deaths were observed. Clinical signs, characterised by closed eyes, abnormal respiratory sound and adhesion of a blood-like substance to the area surrounding
- Gross pathology:
- Effects on organs:
In the male that died, soiled fur and adhesion of a
blood-like substance in the area surrounding the nose was
observed. Internal examination revealed hyperemia in the
small intestine. In the animals that survived, there were no
marked changes in the internal or external findings in both
males and females.
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Not classified
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