Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 443-510-2 | CAS number: 738587-10-5
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Description of key information
None available.
Additional information
The only toxicologically significant findings from this study were in the 1000 mg/kg/bw/day and related to reductions in body weight gain in adult males throughout the treatment period and in adult females during lactation. These effects were considered to be representative of a general systemic effect of S190700 and not related to any effect of reproduction. No effects were seen at the other two dose levels used in the study of 50 and 250 mg/kg/bw/day and therefore the study NOEL was considered to be 250 mg/kg/bw/day. This NOEL was considered to be appropriate for determination of the oral DNEL for reproduction.
Short description of key information:
The only fertility information available on the test substance is an OECD 421 reproduction/development toxicity screening study.
Effects on developmental toxicity
Description of key information
The only toxicity/teratogenicity information available on the test substance is an OECD 421 reproduction/development toxicity screening study.
Additional information
See discussion on fertility.
Justification for classification or non-classification
The only toxicologically significant findings in the OECD 421 reproduction/development toxicity screening in the 1000 mg/kg/bw/day and related to reductions in body weight gain in adult males throughout the treatment period and in adult females during lactation. These effects were considered to be representative of a general systemic effect of the test substance and not related to any direct effect on reproduction. The test substance was therefore considered non-classifiable for effects on reproduction.
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
