Registration Dossier
Registration Dossier
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EC number: 232-989-1 | CAS number: 9080-17-5
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well-documented guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- no
Test material
- Reference substance name:
- Disodium sulphide
- EC Number:
- 215-211-5
- EC Name:
- Disodium sulphide
- Cas Number:
- 1313-82-2
- IUPAC Name:
- disodium sulfide
- Details on test material:
- Name of the test substance used in the study report: Schwefelnatrium Schuppen 60%
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 50, 150, 500, 5000 mg/kg
- No. of animals per sex per dose:
- 5
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- 254 mg/kg bw
- Mortality:
- 50 mg/kg - 0%; 150 mg/kg - 10%; 500 mg/kg - 90%; 5000 mg/kg - 100%
- Clinical signs:
- other: highest dose level: sedation, somnolence, dyspnea, ataxia, sluggished movements, lateral and abdominal position, ruffled fur
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
