Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc

Endpoint summary

Description of key information

Reaction product of 2-hydroxybenzoic acid, styrene and oxozinc was tested for acute toxicity following oral application in female RjHan:WI rats. The oral LD50 was determined to be >2000 mg/kg bw.

Key value for chemical safety assessment

Acute toxicity: via oral route

Endpoint conclusion

Dose descriptor:

discriminating dose

Value:

2 000 mg/kg bw

Additional information

In an acute oral toxicity study according to OECD TG 423 (2001) and under GLP, 2 groups/3 females of fasted, young adult Sprague-Dawley rats were given a single oral dose of the test substance in Dimethyl Sulfoxide (DMSO) at 2000 mg/kg bw and consecutively observed for 14 days. Initially, 3 females (Group 1) were treated at a dose level of 2000 mg/kg bw. As no mortality was observed, a confirmatory group (Group 2) was treated at the same dose level. One animal died in the confirmatory group, therefore no further testing was required according to OECD 423 (2001) and Commission Regulation (EC) No 440/2008. No mortality occurred and no signs of toxicity were observed during the 14 day observation period. All animals showed slight clinical signs of piloerection and production of soft faeces 4 hours after dosing. Recovery had occurred within 24 hours and no other signs of reaction to treatment were apparent during the 14 day observation period. The bodyweight gain was not impaired. Thus, the oral LD50 was determined to be >2000 mg/kg bw. Under the conditions of this study, the acute oral LD50 value of the test item Reaction Product of 2-hydroxybenzoic acid, styrene and oxozinc was found to be above 2000 mg/kg bw in female RjHan:WI rats.

Justification for classification or non-classification

Based on data available for acute toxicity Reaction Product of 2-hydroxybenzoic acid, styrene and oxozinc was not classified and labelled according to Directive 67/548/EEC (DSD) and Regulation (EC) No 1272/2008 (CLP).