2-aminoethanol

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Meets generally accepted scientific standards, acceptable for assessment.

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1966

Report date:

1966

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Principles of method if other than guideline:

Groups of 5 rats/sex were treated by gavage with 200, 400, 800, 1000, 1250, 1600 or 3200 ml/kg bw of the test material to determine the acute oral LD50

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-aminoethanol

EC Number:

205-483-3

EC Name:

2-aminoethanol

Cas Number:

141-43-5

Molecular formula:

C2H7NO

IUPAC Name:

2-aminoethanol

Details on test material:

- Name of test material (as cited in study report): monoethanolamine
- no further data

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 2 % (200 ml/kg), 4 % (400 and 800 ml/kg), 8 % (1000 and 1250 ml/kg) and 20 % (1600 and 3200 ml/kg)

Doses:

200, 400, 800, 1000, 1250, 1600, 3200 ml/kg bw

No. of animals per sex per dose:

5 males, 5 females

Control animals:

no

Details on study design:

- Duration of observation period following administration: 7 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

ca. 1 515 mg/kg bw

Remarks on result:

other: ca. 1500 ml/kg bw (calculated with a specific density of 1.01 g/ml

Mortality:

All males and females treated with 3200 ml/kg died within 24 hours. Two males and 4 females treated with 1600 ml/kg died within the first 48 hours. None of the animals treated with 200, 400, 800, 1000 or 1250 ml/kg died.

Clinical signs:

Animals treated with 3200 or 1600 ml/kg exhibited calm behavior and abdominal position after application. Animals treated with 1600 ml/kg also exhibited calm behavior, slight staggering and piloerection in the following observation days, until day 7 (when normal behavior was noted). Squatting posture and calm behavior were noted up to 24 hours after treatment with 1250 ml/kg and 1000 mg/kg bw. No clinical signs were noted in these groups from day 4 onward. No clinical signs were noted in animals treated with 800 or 400 ml/kg bw. Slight staggering was noted in animals treated with 200 ml/kg on study days 1 and 2. No clinical signs were noted later on in this group.

Body weight:

nothing abnormal reported

Gross pathology:

Animals that survived to study termination showed no internal abnormalities at necropsy.